93 Results for "

mitochondrial enzyme

" in MedChemExpress (MCE) Product Catalog:
Products (93)

93 Results for "mitochondrial enzyme" in MCE Product Catalog:

23
Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%)
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23 Publications Verification
Cat. No.: HY-N0171A
CAS No.: 83-46-5
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
Category:  

Cardiovascular Disease Leguminosae Glycine max (L.) merr Plants Disease Research Fields Inflammation/Immunology Steroids

Target:  

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
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23
Beta-Sitosterol (purity>80%)
Beta-Sitosterol (purity>80%)
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23 Publications Verification
Cat. No.: HY-N0171
CAS No.: 83-46-5
Category:  

Cardiovascular Disease other families Leguminosae Plants Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Steroids

Target:  

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
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14
α-Lipoic Acid
α-Lipoic Acid
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14 Cited Publications
Cat. No.: HY-N0492
CAS No.: 1077-28-7
Synonyms: Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid
Category:  

Infection Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis

α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
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14
α-Lipoic Acid sodium
α-Lipoic Acid sodium
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14 Cited Publications
Cat. No.: HY-N0492A
CAS No.: 2319-84-8
Synonyms: Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium
Category:  

Infection Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis

α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
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13
Sulfaphenazole
Sulfaphenazole
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13 Cited Publications
Cat. No.: HY-B1218
CAS No.: 526-08-9
Target:  

Cytochrome P450 Antibiotic Bacterial Necroptosis Apoptosis

Research Areas:  

Infection Cardiovascular Disease

Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .
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12
Tetrazolium Red
Tetrazolium Red
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12 Cited Publications
Cat. No.: HY-D0714
CAS No.: 298-96-4
Synonyms: 2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC
Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm .
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10
Lipoic acid
Lipoic acid
0 Images
10 Cited Publications
Cat. No.: HY-18733
CAS No.: 1200-22-2
Synonyms: (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer

Target:  

Endogenous Metabolite Reactive Oxygen Species (ROS) Mitochondrial Metabolism

Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
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5
WST-1
WST-1
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5 Cited Publications
Cat. No.: HY-136976
CAS No.: 150849-52-8
Purity:  ≥98.0%
WST-1 is a kind of water-soluble tetrazolium salt. WST induces the intracellular mitochondrial dehydrogenase to conduct NADH-dependent enzyme digestion reaction, releasing the water-soluble methyl benzene product. WST-1 can be used for the detection of cell proliferation and cytotoxicity, via the determination of the light absorption value at 450 nm .
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4
Orotic acid
Orotic acid
0 Images
4 Cited Publications
Cat. No.: HY-N0157
CAS No.: 65-86-1
Synonyms: 6-Carboxyuracil; Vitamin B13
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:  

Nucleoside Antimetabolite/Analog Endogenous Metabolite

Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats .
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4
Orotic acid zinc
Orotic acid zinc
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4 Cited Publications
Cat. No.: HY-N0157A
CAS No.: 68399-76-8
Synonyms: 6-Carboxyuracil zinc; Vitamin B13 zinc
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Nucleoside Antimetabolite/Analog Endogenous Metabolite

Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats .
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3
Miglitol
Miglitol
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3 Cited Publications
Cat. No.: HY-B0481
CAS No.: 72432-03-2
Synonyms: BAY1099; BAY-m1099
Target:  

Glycosidase AMPK Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease

Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets .
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2
Cytochrome C
Cytochrome C
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2 Cited Publications
Cat. No.: HY-125857
CAS No.: 9007-43-6
Purity:  99.9%
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .
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2
Beta-Sitosterol (Standard)
Beta-Sitosterol (Standard)
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2 Cited Publications
Cat. No.: HY-N0171R
CAS No.: 83-46-5
Synonyms: β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))
Category:  

Cardiovascular Disease other families Leguminosae Plants Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Steroids

Target:  

Reference Standards Apoptosis Endogenous Metabolite

Beta-Sitosterol (Standard) is the analytical standard of Beta-Sitosterol. This product is intended for research and analytical applications. Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
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2
Momordicine I
Momordicine I
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2 Cited Publications
Cat. No.: HY-122949
CAS No.: 91590-76-0
Purity:  ≥97.0%
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn.

Target:  

Oxidative Phosphorylation AMPK Keap1-Nrf2 Src Akt Apoptosis NO Synthase mTOR PI3K Autophagy Reactive Oxygen Species (ROS) Endogenous Metabolite Mitochondrial Metabolism NF-κB c-Met/HGFR DGK Interleukin Related STAT

Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the PI3K/Akt pathway, reducing oxidative stress and inflammation. Momordicine I inhibits AKT1, IL-6, and SRC, suggesting its potential application in type 2 diabetes .
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2
CYP11A1 Antibody
CYP11A1 Antibody
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2 Cited Publications
Cat. No.: HY-P81223
Synonyms: Cholesterol 20 22 desmolase antibody Cholesterol desmolase antibody; Cholesterol monooxygenase (side chain cleaving) antibody; Cholesterol side chain cleavage enzyme antibody; Cholesterol side chain cleavage enzyme mitochondrial antibody; Cholesterol side-chain cleavage enzyme antibody; CP11A_HUMAN antibody; CYP11A antibody; CYP11A1 antibody; CYPXIA1 antibody; Cytochrome P450 11A1 antibody; Cytochrome P450 11A1 mitochondrial antibody; Cytochrome P450 family 11 subfamily A polypeptide 1 antibody; Cytochrome P450 subfamily XIA antibody; Cytochrome P450(scc) antibody; Cytochrome P450C11A1 antibody; mitochondrial antibody; P450SCC antibody; Steroid 20 22 lyase antibody;

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Mouse, Rat

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1
N-Propargylglycine
N-Propargylglycine
0 Images
1 Cited Publications
Cat. No.: HY-142035
CAS No.: 58160-95-5
Purity:  99.70%
Target:  

Mitochondrial Metabolism

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

N-Propargylglycine is a brain-penetrant and orally active PRODH inhibitor. N-Propargylglycine covalently modifies enzyme-bound FAD and active site lysine, causing enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. N-Propargylglycine induces UPRmt, upregulates mitochondrial chaperones and YME1L1, enhances mitochondrial proteostasis, blocks astrocytic L-proline consumption, and abolishes L-proline’s ATP-maintaining and viability-protective effects. N-Propargylglycine stimulates neural processes, increases brain proline, hydroxyproline, and sarcosine levels, partially normalizes Huntington’s disease whole brain transcriptomes. N-Propargylglycine reduces hyperoxaluria, prevents calcium oxalate stone formation, reduces kidney tubular damage, and restores weight and survival in Grhpr knockout mice. N-Propargylglycine can be used for the research of breast cancer, neurodegenerative disorders, Huntington’s disease, and primary hyperoxaluria type 2 .
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1
α-Lipoic Acid-d5
α-Lipoic Acid-d5
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1 Cited Publications
Cat. No.: HY-N0492S
CAS No.: 1189471-66-6
Synonyms: Thioctic acid-d5; (±)-α-Lipoic acid-d5; DL-α-Lipoic acid-d5
α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells .
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1
Fenchlorphos
Fenchlorphos
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1 Cited Publications
Cat. No.: HY-B1093
CAS No.: 299-84-3
Target:  

Environmental Pollutants Parasite Cholinesterase (ChE)

Research Areas:  

Infection

Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction .
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1
Lipoic acid (Standard)
Lipoic acid (Standard)
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1 Cited Publications
Cat. No.: HY-18733R
CAS No.: 1200-22-2
Synonyms: (R)-(+)-α-Lipoic acid(Standard); R-(+)-Thioctic acid (Standard)
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer

Target:  

Reference Standards Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species (ROS)

Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
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1
PRDX5/Peroxiredoxin-5 Protein, Mouse (His)
PRDX5/Peroxiredoxin-5 Protein, Mouse (His)
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1 Cited Publications
Cat. No.: HY-P73375
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX5; B166; Peroxiredoxin 5; Thioredoxin-Dependent Peroxiredoxin 5; AOEB166; Peroxiredoxin-5, mitochondrial; ACR1; Alu Co-Repressor 1; PLP; Peroxiredoxin V; Peroxisomal Antioxidant enzyme; MGC142285; Liver Tissue 2D-Page Spot 71B; MGC117264; Thioredoxin
Species:  
Mouse
Source:  
E. coli
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