molecular conjugation

By Targets:	ADC Linker (4) Apoptosis (1) Biochemical Assay Reagents (3) Drug Intermediate (1) Drug-Linker Conjugates for ADC (1) Fluorescent Dye (2) PROTAC Linkers (6) TGF-beta/Smad (1) Topoisomerase (1) VEGFR (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

Targets Recommended: Molecular Glues

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1390A

Sulfo-Cy5-Mal	Fluorescent Dye	Others
Sulfo-Cy5-Mal is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .

HY-163099

P5(PEG24)-VC-PAB-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase Apoptosis	Cancer
P5 (PEG24)-VC-PAB-Exatecan is a TOP1 inhibitor payload with antibody-conjugation-dependent activity. Conjugation of P5 (PEG24)-VC-PAB-Exatecan with Trastuzumab (HY-P9907) generates a DAR8 antibody-drug conjugate (ADCs) with antibody-like pharmacokinetic properties. P5 (PEG24)-VC-PAB-Exatecan induces S-phase and G2-M-phase cell cycle arrest, DNA damage and apoptosis in target-positive tumor cells, and releases damage-associated molecular patterns (DAMP) related to immunogenic cell death (ICD). The ADCs prepared from it exert bystander killing effects on non-target tumor cells. ADCs based on P5 (PEG24)-VC-PAB-Exatecan exhibit linker stability in vitro and in vivo, show in vivo efficacy, and can be used in research related to HER2-positive cancers .

HY-W106411

DTME Dithio-bis-maleimidoethane	Biochemical Assay Reagents	Others
DTME (dithio-bis-maleimidoethane) is a homobifunctional, maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH). DTME, whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge, can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds. DTME allows crosslinks that can be cleaved with reducing agents such as DTT (HY-15917). DTME is commonly utilized to explore and characterize protein structure, particularly oligomerization, or protein interactions .

HY-P5107

Low molecular weight protamine LMWP; TDSP5	VEGFR	Cancer
Low molecular weight protamine (LMWP;TDSP5) is a truncated arginine-rich protamine peptide, as well as a heparin/low-molecular-weight heparin antidote and a cell-penetrating delivery carrier. Low molecular weight protamine neutralizes heparin-induced anticoagulant activities, including aPTT, anti-Xa and anti-IIa activities, and also neutralizes anti-Xa activity of commercially available low-molecular-weight heparin preparations. Low molecular weight protamine translocates across mammalian cell membranes, delivers conjugated impermeable molecules across tumor tissues, enhances skin permeability of conjugated epidermal growth factor, and accelerates wound healing when conjugated with epidermal growth factor. Low molecular weight protamine retains the in vitro cell proliferation activity of conjugated EGF, and also enables site-specific conjugation with peptides or proteins via genetic recombination. Low molecular weight protamine can be used in studies related to colon adenocarcinoma, skin wounds and diabetic skin wounds .

HY-W1048851B

4-Arm-PEG10000-Maleimide 4-Arm-PEG10000-Mal	Biochemical Assay Reagents	Others
4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .

HY-151697

DACN(Tos2)	ADC Linker	Others
DACN(Tos2) is a a click chemistry reagent containing an cycloalkynes group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. DACN(Tos2) through such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes. DACN(Tos2) can be used for the research of molecular conjugation .

HY-151795

DACN(Tos) hydrochloride	ADC Linker	Others
DACN(Tos) hydrochloride is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions, such strain-promoted azide-alkyne cycloadditions (SPAAC) by using cycloalkynes. DACNs possesses high thermal and chemical stability along with comparable click reactivity. DACN(Tos) hydrochloride can be used for the research of molecular conjugation .

HY-W1048572D

N3-PEG3400-NH2 Azide-PEG3400-Amine	PROTAC Linkers	Others
N3-PEG3400-NH2 (Azide-PEG3400-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG3400-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-151766

DACN(Tos,Suc-OH)	ADC Linker	Others
DACN(Tos,Suc-OH) is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. DACNs possess high thermal and chemical stability along with comparable click reactivity .

HY-P5107A

Low molecular weight protamine acetate LMWP acetate; TDSP5 acetate	VEGFR	Cancer
Low molecular weight protamine acetate (LMWP acetate;TDSP5 acetate) is a truncated arginine-rich protamine peptide, which also acts as an antidote for heparin/low molecular weight heparin and a cell-penetrating delivery vector. Low molecular weight protamine acetate neutralizes heparin-induced anticoagulant activities, including aPTT, anti-Xa and anti-IIa activities. Low molecular weight protamine acetate translocates across mammalian cell membranes, delivers conjugated impermeable molecules through tumor tissues, enhances the skin permeability of conjugated epidermal growth factor, and accelerates wound healing when conjugated with epidermal growth factor. Low molecular weight protamine acetate retains the in vitro cell proliferation activity of conjugated EGF, and also enables site-specific conjugation with peptides or proteins via genetic recombination. Low molecular weight protamine acetate can be used in studies related to colon cancer, skin wounds and diabetic skin wounds .

HY-D1390

Sulfo-Cy5-Mal potassium	Fluorescent Dye	Others
Sulfo-Cy5-Mal potassium is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal potassium specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal potassium can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .

HY-W1048572C

N3-PEG1000-NH2 Azide-PEG1000-Amine	Biochemical Assay Reagents	Others
N3-PEG1000-NH2 (Azide-PEG1000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG1000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-W1048572A

N3-PEG2000-NH2	PROTAC Linkers	Others
N3-PEG2000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG2000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-W1048572H

N3-PEG10000-NH2 Azide-PEG10000-Amine	PROTAC Linkers	Others
N3-PEG10000-NH2 (Azide-PEG10000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG10000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-W1048572I

N3-PEG20000-NH2 Azide-PEG20000-Amine	PROTAC Linkers	Others
N3-PEG20000-NH2 (Azide-PEG20000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG20000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-151754

DACN(Tos2,6-OH)	ADC Linker	Others
DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity . DACN(Tos2,6-OH) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P11697

Fmoc-PNA-maleimide-OH	Drug Intermediate	Others
Fmoc-PNA-maleimide-OH is a Fmoc-protected functionalized peptide nucleic acid monomer featuring a maleimide group for thiol-reactive conjugation. Fmoc-PNA-maleimide-OH can be used in constructing PNA conjugates for molecular assembly applications.

HY-W1048572E

N3-PEG5000-NH2	PROTAC Linkers	Others
N3-PEG5000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG5000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-W1048572J

N3-PEG40000-NH2 Azide-PEG40000-Amine	PROTAC Linkers	Others
N3-PEG40000-NH2 (Azide-PEG40000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG40000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .

HY-P11753

IKVAVC	TGF-beta/Smad	Neurological Disease Inflammation/Immunology
IKVAVC is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus. IKVAVC retains all the biological activities of the original IKVAV, mainly acting as a neural adhesion/differentiation signaling peptide, and is equipped with an engineered linker arm that enables covalent conjugation to molecular materials. IKVAV inhibits the migration and activation of fibroblasts, downregulates the TGF-β1 signaling pathway and endoplasmic reticulum stress, and promotes nerve repair. IKVAV regulates the phenotype of macrophages, shifting them from the pro-inflammatory M1 type to the pro-reparative M2 type .

Cat. No.	Product Name

HY-L220

Biotoxin Library	90 compounds
Biotoxins, also referred to as natural toxins, are chemical substances produced by plants, animals, or microorganisms that exert toxic effects on other living organisms. Due to unique biological activities, biotoxins have been widely applied in molecular biology, physiology, pharmacology, and the clinical diagnosis and treatment of various human diseases, becoming an important source of natural drug development. Biotoxins can specifically bind to and interfere with intracellular signaling molecules or receptors, thereby altering cellular signaling processes. Leveraging this characteristic, biotoxins can be used to study the regulatory mechanisms of cellular signaling pathways. For example, neurotoxins such as snake venom peptides can be used to investigate the functional regulation of neurotransmitter receptors and ion channels. Additionally, biotoxins have demonstrated significant potential in drug development across various fields, including neurological diseases, cardiovascular diseases, anticoagulation, and anti-cancer therapies. With advancements in high throughput screening, structural optimization, and antibody-toxin conjugation technologies, numerous biotoxins or their structural analogs have been successfully brought to market, such as Ziconotide, Captopril, Bivalirudin, and Eptifibatide. MCE offers 90 types of biotoxins, including neurotoxins, cardiotoxins, mycotoxins, and more.

Biotoxin Library

90 compounds

Biotoxins, also referred to as natural toxins, are chemical substances produced by plants, animals, or microorganisms that exert toxic effects on other living organisms. Due to unique biological activities, biotoxins have been widely applied in molecular biology, physiology, pharmacology, and the clinical diagnosis and treatment of various human diseases, becoming an important source of natural drug development. Biotoxins can specifically bind to and interfere with intracellular signaling molecules or receptors, thereby altering cellular signaling processes. Leveraging this characteristic, biotoxins can be used to study the regulatory mechanisms of cellular signaling pathways. For example, neurotoxins such as snake venom peptides can be used to investigate the functional regulation of neurotransmitter receptors and ion channels. Additionally, biotoxins have demonstrated significant potential in drug development across various fields, including neurological diseases, cardiovascular diseases, anticoagulation, and anti-cancer therapies. With advancements in high throughput screening, structural optimization, and antibody-toxin conjugation technologies, numerous biotoxins or their structural analogs have been successfully brought to market, such as Ziconotide, Captopril, Bivalirudin, and Eptifibatide.

MCE offers 90 types of biotoxins, including neurotoxins, cardiotoxins, mycotoxins, and more.

Cat. No.	Product Name	Type