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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
nuclear import protein
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "nuclear import protein" in MCE Product Catalog:
Cat. No.: HY-170316
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .
Synonyms: AP1867-PEG2-JQ1; AP-PEG2-JQ1
Target:
Research Areas:
NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a “carrier” for co-import and nuclear trapping of cytosolic proteins .
Cat. No.: HY-159828
CAS No.: 2568911-72-6
Synonyms: VH-499; VH4011499
Dezecapavir (VH-499) is a HIV-1 capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of HIV-1 laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the HIV-1 life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to HIV-1 infection .
Cat. No.: HY-P10600A
Cat. No.: HY-P3838
CAS No.: 309247-51-6
Cat. No.: HY-P10600
CAS No.: 1105053-46-0
Cat. No.: HY-P71162
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NIP7; 60S Ribosome Subunit Biogenesis protein NIP7 Homolog; Nucleolar Pre-RRNA Processing protein NIP7; FLJ10296; KD93; NIP7, Nucleolar Pre-RRNA Processing protein; HSPC031; nuclear import 7 Homolog (S. Cerevisiae); CGI-37; nuclear import 7 Homolog
Species:
Human
Source:
E. coli
Cat. No.: HY-P11948
CAS No.: 253328-16-4
Cat. No.: HY-P11948A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
