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Cat. No.: HY-P11948A

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c-Myc NLS TFA

Name: c-Myc NLS TFA
Brand: MedChemExpress
SKU: HY-P11948A
Price: 75.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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c-Myc NLS TFA is a non-canonical nuclear localization signal (NLS) derived from the oncoprotein c-Myc, with the sequence PAAKRVKLD and containing 3 basic amino acids. c-Myc NLS TFA mediates the nuclear localization of fusion proteins, and all its regions are essential or play important roles in nuclear import. c-Myc NLS TFA can target fused pyruvate kinase to the nuclei of transfected cells.

For research use only. We do not sell to patients.

Formula: C₄₄H₈₀N₁₄O₁₂·xC₂HF₃O₂
Molecular Weight:997.19 (free base)

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

c-Myc NLS TFA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

c-Myc NLS TFA directs recombinant chicken pyruvate kinase to localize in the nuclei of transfected COS7 cells, in which the upstream PAA tripeptide and downstream LD dipeptide play critical or important roles in efficient nuclear localization^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 997.19 (free base)
Formula C₄₄H₈₀N₁₄O₁₂·xC₂HF₃O₂
SMILES

O=C(O)C(F)(F)F.O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]1NCCC1.[x]
Sequence

Pro-Ala-Ala-Lys-Arg-Val-Lys-Leu-Asp
Sequence Shortening

PAAKRVKLD
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Makkerh JP, et al. Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids. Current biology : CB. 1996 Aug 01;6(8):1025-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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