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Results for "

nuclease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Arf Family GTPase (1) Bacterial (1) Biochemical Assay Reagents (6) DNA/RNA Synthesis (11) Drug Intermediate (2) Endogenous Metabolite (3) Endonuclease (3) HBV (1) Liposome (2) Macrophage migration inhibitory factor (MIF) (1) MicroRNA (1) mRNA (3) Nucleoside Antimetabolite/Analog (3) PDGFR (1) Phosphatase (1) Phosphoramidites (2) Reference Standards (2) RSV (1)
By Research Areas:	Cancer (16) Infection (7) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Pegylated Lipids (2) Guanosine (3) Nucleotide Analogs (1) Aptamers (1) Nucleoside Analogs (3) Adenine (1) mRNA (3) Phosphoramidites (2) Adenine Nucleotide (1) Gene Editing (2) Guanine (1)

Inhibitors & Agonists

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MCE Kits

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Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131160

Nuclease, Serratia marcescens Serratia marcescens nuclease	Biochemical Assay Reagents	Inflammation/Immunology
Serratia marcescens nuclease (EC 3.1.30.2) is a nonspecific nuclease. Serratia marcescens nuclease has broad utility due to its potent digestive activity toward both DNA and RNA .

HY-128729

DNA2 inhibitor C5 Maximum Cited Publications 10 Publications Verification	DNA/RNA Synthesis	Cancer
DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC₅₀ of 20 μM. DNA2 inhibitor C5 inhibits the *nuclease, DNA-dependent ATPase, helicase*, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research .

HY-P2773

Nuclease S1, Aspergillus oryzae	DNA/RNA Synthesis	Others
Nuclease S1, Aspergillus oryzae is a specific endonuclease that degrades single stranded DNA (ssDNA) and RNA. Nuclease S1 can also remove protruding single-strand ends from double-stranded DNA .

HY-21997

DMT-2'fluoro-da(bz) amidite	Phosphoramidites DNA/RNA Synthesis Drug Intermediate	Others
DMT-2'fluoro-da(bz) amidite is a key intermediate for synthesizing antisense oligonucleotides with high nuclease resistance, high RNA binding affinity, and maintained base-pair specificity .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. 2'-O,4'-C-Methyleneguanosine is a substrate for KOD DNA polymerase, which incorporates LNA-G nucleotides into growing DNA strands, including consecutive incorporations , to generate full-length extension products .

HY-W440823A

DSPE-PEG1000-Amine ammonium DSPE-PEG1000-NH2 ammonium	Liposome	Cancer
DSPE-PEG1000-Amine (DSPE-PEG1000-NH2) ammonium is a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol conjugate with a terminal amino group. DSPE-PEG1000-Amine ammonium can functionalize the surface of PLGA-lecithin-PEG core-shell nanoparticles to introduce positive surface charges. The amino group of DSPE-PEG1000-Amine ammonium can be converted into an aromatic aldehyde to react with the acetone-protected aromatic hydrazide on the surface of bovine carbonic anhydrase (BCA) molecules .

HY-P2963

Nuclease P1 1 Publications Verification	Endogenous Metabolite	Others
Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries . Nuclease P1 can be obtained by fermentation of Penicillium citrinum: through extraction process, ultrafiltration concentration, drying and purification, etc.

HY-156262

DEPC-Treated Water	Biochemical Assay Reagents	Others
DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity .

HY-173189A

2-5A pentasodium solution (100 mM) 2′,5′-ApApA pentasodium; 2′,5′-trioligoadenylate pentasodium; 5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine pentasodium	RSV DNA/RNA Synthesis	Infection Cancer
2-5A (2′,5′-ApApA) pentasodium solution 100 mM is a high-affinity (K_a=0.04 nM) RNase L binder. 2-5A pentasodium solution 100 mM activates the nuclease activity of latent RNase L to cleave single-stranded RNA by inducing conformational changes and dimerization of latent RNase L, thereby mediating critical antiviral responses and enhancing interferon effects. 2-5A pentasodium solution 100 mM not only effectively inhibits Rauscher murine leukemia virus replication, reduces viremia and splenomegaly, but also enhances antileukemic efficacy when combined with amphotericin B and exhibits favorable high-dose tolerance. 2-5A pentasodium solution 100 mM is an important tool molecule for investigating the pathological mechanisms of viral infection, hereditary prostate cancer and leukemia .

HY-D0841

Guanidine thiocyanate 3 Publications Verification	Endogenous Metabolite	Infection Cancer
Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction .

HY-115581A

Thymidine 3',5'-diphosphate tetrasodium Deoxythymidine 3′,5′-diphosphate tetrasodium; pdTp tetrasodium	Apoptosis MicroRNA	Cancer
Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5- ²H₂] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions .

HY-170844

MU147	Endonuclease	Cancer
MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells .

HY-136638

ML328	DNA/RNA Synthesis Bacterial	Infection
ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC₅₀ values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection .

HY-P2754

Micrococcal nuclease	Endonuclease	Infection
Micrococcal nuclease is an endonuclease derived from Staphylococcus aureus. Micrococcal nuclease is able to digest both single and double-stranded DNA (ssDNA and dsDNA) and RNA, and can cleave and hydrolyze the AT or AU-rich regions specifically. Micrococcal nuclease could be used as an indicator of Staphylococcus aureus contamination .

HY-E70220

AsCas12a Nuclease	Biochemical Assay Reagents	Others
AsCas12a Nuclease is a nuclease, and can specifically cutting double-stranded DNA. AsCas12a Nuclease can be used for gene edited study .

HY-128712

NCGC00029283	DNA/RNA Synthesis	Cancer
NCGC00029283 is a *werner syndrome helicase-nuclease* (WRN) helicase inhibitor with IC₅₀**s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .

HY-124493

Aluminon 3 Publications Verification ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium	Biochemical Assay Reagents	Others
Aluminon (ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium) is a complexometric titration indicator and can also be used as a nuclease inhibitor affecting transfection. Aluminon is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W060316

β-Thujaplicinol 3-Hydroxy-5-isopropyltropolone	HBV DNA/RNA Synthesis	Infection
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC₅₀ values of 5.9 and 2.3 μM, respectively .

HY-170845

MU1409	Endonuclease	Cancer
MU1409 is an inhibitor of MRE11 nuclease with an IC₅₀ of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC₅₀ values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers .

HY-160053

Gint4.T aptamer sodium	PDGFR	Cancer
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .

HY-155887

DSPE-PEG-Amine, MW 3400 ammonium DSPE-PEG-NH2, MW 3400 ammonium	Liposome	Cancer
DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research .

HY-E70579

Exonuclease III	DNA/RNA Synthesis	Others
Exonuclease III is a nuclease for specifically targeting double-stranded DNA (dsDNA). Exonuclease III is a DNA repair-associated nuclease with apurinic/apyrimidinic (AP)-endonuclease and 3'→5' exonuclease activities. Exonuclease III cleaves the ssDNA at 5'-bond of phosphodiester from 3' to 5' end by both exonuclease and endonuclease activities .

HY-21286

N2-Isobutyryl-2'-O-methylguanosine	Drug Intermediate	Others
N2-Isobutyryl-2'-O-methylguanosine is a nucleic acid synthesis intermediate (e.g., used in antisense oligonucleotides, mRNA modification), for example, it is a key monomer for the synthesis of 2'-O-methyl oligoribonucleotides. N2-Isobutyryl-2'-O-methylguanosine enables the final product to form stable double strands with complementary RNA and is not easily degraded by nucleases. N2-Isobutyryl-2'-O-methylguanosine is mainly used in molecular biology research, and can be used to prepare RNA hybridization probes or participate in related biochemical research such as pre-mRNA splicing mechanisms .

HY-E70218

Cas9 Nuclease	Others	Others
Cas9 Nuclease is cloned from wild-type Streptococcus pyogenes. Cas9 Nuclease can be used in the area of molecular diagnosis to achieve highly sensitive and specific detection of pathogens ^[1].

HY-W073825

N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a 2’-0-(2-methoxyethyl) guanosine derivative. 2’-0-methoxyethyl nucleoside derivatives can enhance the affinity with RNA and increase the resistance of oligonucleotides to nucleases.

HY-W115309

DMT-2'-F-iBu-G 5'-DMT-2'-F-ibu-dG	Phosphoramidites Nucleoside Antimetabolite/Analog	Others
DMT-2'-F-iBu-G (5'-DMT-2'-F-ibu-dG) is a modified oligonucleotide. 2'-deoxy-2'-fluoro-modified oligonucleotides shows high nuclease resistant and retained exceptional binding affinity to the RNA targets .

HY-128729R

DNA2 inhibitor C5 (Standard)	Reference Standards DNA/RNA Synthesis	Cancer
DNA2 inhibitor C5 (Standard) is the analytical standard of DNA2 inhibitor C5 (HY-128729). This product is intended for research and analytical applications. DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC₅₀ of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research.

HY-174794

Cas9-T2A-GFP mRNA	mRNA	Others
The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments.

HY-D0841R

Guanidine thiocyanate (Standard)	Endogenous Metabolite Reference Standards	Infection Cancer
Guanidine thiocyanate (Standard) is the analytical standard of Guanidine thiocyanate. This product is intended for research and analytical applications. Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction .

HY-174793

Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP)	mRNA	Others
The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments. The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.

HY-E70219

SpCas9 D10A Nickase	Biochemical Assay Reagents	Others
SpCas9 D10A Nickase is a mutant of the Cas9 protein. SpCas9 D10A Nickase retains the function of a cleavage domain of Cas9 nuclease and specifically cleaves the target single strand to form a nick. SpCas9 D10A Nickase reduces off-target effects .

HY-E70433

SaCas9	Biochemical Assay Reagents	Others
SaCas9 is a nuclease. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-115581

Thymidine 3',5'-disphosphate Deoxythymidine 3′,5′-diphosphate; pdTp	Apoptosis	Cancer
Thymidine 3',5'-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit) and inhibits SND1 activity. Thymidine 3',5'-disphosphate exhibits anti-tumor efficacy in vivo .

HY-182935

PAANIB-1	Macrophage migration inhibitory factor (MIF)	Neurological Disease
PAANIB-1 is a *parthanatos associated apoptosis-inducing factor nuclease* (PAAN)/macrophage migration inhibitor factor (MIF)** inhibitor. PAANIB-1 exhibits neuroprotective activity. PAANIB-1 can be used for the research of Parkinson's disease .

HY-185053

Cas12a mRNA	mRNA	Infection
Cas12a mRNA encodes the Cas12a protein. Cas12a is a nuclease .

HY-182634

NCGC00063279	DNA/RNA Synthesis Phosphatase	Cancer
NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma .

HY-180573

ART5537	Arf Family GTPase	Cancer
ART5537 is a selective EXO1 inhibitor with a IC₅₀ of 3.4 nM and a K_d of 6.8 nM. ART5537 exerts cellular homologous recombination (HR) inhibition with EC₅₀ of 7.2 nM in HAP1 parental cells. ART5537 shows >200-fold selectivity over a panel of the wider nuclease superfamily. ART5537 exerts biological effects that are exclusively driven by EXO1 inhibition. ART5537 demonstrates sensitization to ionizing radiation and synergy with Olaparib (HY-10162). ART5537 can be used for research in breast cancer and colorectal adenocarcinoma .

Cat. No.	Product Name	Type

HY-21997

DMT-2'fluoro-da(bz) amidite	Biochemical Assay Reagents
DMT-2'fluoro-da(bz) amidite is a key intermediate for synthesizing antisense oligonucleotides with high nuclease resistance, high RNA binding affinity, and maintained base-pair specificity .

HY-W440823A

DSPE-PEG1000-Amine ammonium DSPE-PEG1000-NH2 ammonium	Biochemical Assay Reagents
DSPE-PEG1000-Amine (DSPE-PEG1000-NH2) ammonium is a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol conjugate with a terminal amino group. DSPE-PEG1000-Amine ammonium can functionalize the surface of PLGA-lecithin-PEG core-shell nanoparticles to introduce positive surface charges. The amino group of DSPE-PEG1000-Amine ammonium can be converted into an aromatic aldehyde to react with the acetone-protected aromatic hydrazide on the surface of bovine carbonic anhydrase (BCA) molecules .

DSPE-PEG1000-Amine ammonium

DSPE-PEG1000-NH2 ammonium

Biochemical Assay Reagents

DSPE-PEG1000-Amine (DSPE-PEG1000-NH2) ammonium is a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol conjugate with a terminal amino group. DSPE-PEG1000-Amine ammonium can functionalize the surface of PLGA-lecithin-PEG core-shell nanoparticles to introduce positive surface charges. The amino group of DSPE-PEG1000-Amine ammonium can be converted into an aromatic aldehyde to react with the acetone-protected aromatic hydrazide on the surface of bovine carbonic anhydrase (BCA) molecules .

HY-156262

DEPC-Treated Water	Biochemical Assay Reagents
DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity .

HY-D0841

Guanidine thiocyanate 3 Publications Verification	Biochemical Assay Reagents
Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction .

HY-124493

Aluminon 3 Publications Verification ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium	Biochemical Assay Reagents
Aluminon (ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium) is a complexometric titration indicator and can also be used as a nuclease inhibitor affecting transfection. Aluminon is a kind of biological materials or organic compounds that are widely used in life science research .

HY-155887

DSPE-PEG-Amine, MW 3400 ammonium DSPE-PEG-NH2, MW 3400 ammonium	Biochemical Assay Reagents
DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research .

DSPE-PEG-Amine, MW 3400 ammonium

DSPE-PEG-NH2, MW 3400 ammonium

Biochemical Assay Reagents

DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research .

HY-D0841R

Guanidine thiocyanate (Standard)	Biochemical Assay Reagents
Guanidine thiocyanate (Standard) is the analytical standard of Guanidine thiocyanate. This product is intended for research and analytical applications. Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction .

Guanidine thiocyanate (Standard)

Biochemical Assay Reagents

Guanidine thiocyanate (Standard) is the analytical standard of Guanidine thiocyanate. This product is intended for research and analytical applications. Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction .

Species:	Human (1) Virus (9) Mouse (1) E.coli (1)
Tag:	SUMO (1) His (8) Strep (1) Tag Free (6) Avi (1)
Source:	P. pastoris (1) Sf9 insect cells (1) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78955

	NucA Protein, S. marcescens nuclease; nucA; Endonuclease; nuc; Benzonase nuclease	Others	E. coli
	The NucA protein plays a central role in cellular processes because it catalyzes the hydrolysis of DNA and RNA (both double- and single-stranded) at the 3' position of the phosphodiester bond to generate 5'-phosphorylated single- and double-stranded , tri- and tetra-nucleotides. This multifunctional enzymatic activity emphasizes the importance of NucA in nucleic acid metabolism, as observed in various studies. NucA Protein, S. marcescens is the recombinant NucA protein, expressed by E. coli , with tag free.

HY-P703506

	DNA polymerase Protein, Pyrococcus woesei (His) fusion Pfu DNA polymerase-GTH-Sso7d; DNA polymerase; Pwo polymerase; pol; Pyrococcus woesei; DNA-binding; DNA-directed DNA polymerase; Endonuclease; Hydrolase; nuclease; Nucleotidyltransferase; Transferase; 2.7.7.7	Others	E. coli
	DNA polymerase Protein, Pyrococcus woesei (His) is the recombinant DNA polymerase, expressed by E. coli , with His labeled tag. ,

HY-P703536

	SARS-CoV-2 NSP3 Protein (His) Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (His) is the recombinant virus-derived NSP3, expressed by E. coli, with N-His labeled tag.

HY-P703539

	SARS-CoV-2 NSP7 Protein (His-Avi) Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. SARS-CoV-2 NSP7 Protein (His-Avi) is the recombinant virus-derived NSP7, expressed by E. coli, with C-His-Avi labeled tag.

HY-P703534

	SARS-CoV-2 NSP3 Protein (372a.a) Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (A1-F372) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

HY-P703535

	SARS-CoV-2 NSP3 Protein (183a.a) Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (A1-T183) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

HY-P703537

	SARS-CoV-2 NSP3 Protein (357a.a) Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (I388-R745) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

HY-P703538

	SARS-CoV-2 NSP3 Protein (338a.a) Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; nuclease; Protease; RNA-binding; Thiol protease; Transferase	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. NSP3 Protein, SARS-CoV-2 (E746-K1083) is the recombinant virus-derived NSP3, expressed by E. coli, with tag-free.

HY-P703532

	SARS-CoV-2 NSP16-NSP10 Protein Replicase polyprotein 1ab; ORF1ab polyprotein; rep; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1ab; Endonuclease; Exonuclease; Helicase; Hydrolase; Lyase; Methyltransferase; nuclease Nucleotidyltransferase; Protease; RNA-binding; RNA-directed RNA polymerase; Thiol protease; Transferase;	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. NSP16/NSP10 Protein, SARS-CoV-2 is the recombinant virus-derived NSP16/NSP10, expressed by E. coli, with tag-free.

HY-P703533

	SARS-CoV-2 NSP16-NSP10 Protein (His) Replicase polyprotein 1ab; ORF1ab polyprotein; rep; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1ab; Endonuclease; Exonuclease; Helicase; Hydrolase; Lyase; Methyltransferase; nuclease Nucleotidyltransferase; Protease; RNA-binding; RNA-directed RNA polymerase; Thiol protease; Transferase;	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. NSP16/NSP10 Protein, Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) (His) is the recombinant virus-derived NSP16/NSP10, expressed by E. coli, with His labeled tag.

HY-P703543

	SARS-CoV-2 RdRP Protein (sf9, His, Strep) Replicase polyprotein 1ab; ORF1ab polyprotein; rep; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1ab; Endonuclease; Exonuclease; Helicase; Hydrolase; Lyase; Methyltransferase; nuclease Nucleotidyltransferase; Protease; RNA-binding; RNA-directed RNA polymerase; Thiol protease; Transferase;	Virus	Sf9 insect cells
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. RdRP Protein, Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) (Sf9, His, Strep) is the recombinant virus-derived RdRP, expressed by Sf9 insect cells, with Strep, His labeled tag.

HY-P71514

	RuvC Protein, E.coli (His-SUMO) ruvC; b1863; JW1852; Crossover junction endodeoxyribonuclease RuvC; EC 3.1.22.4; Holliday junction nuclease RuvC; Holliday junction resolvase RuvC	E.coli	E. coli
	RuvC protein is an important component of the RuvA-RuvB-RuvC complex and is essential for the processing of Holliday junctions in gene recombination and DNA repair. As an endonuclease, RuvC resolves Holliday junctions by generating symmetric single-stranded nicks that rely on a central homology core. RuvC Protein, E.coli (His-SUMO) is the recombinant E. coli-derived RuvC protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P704205

	YBX1 Protein, Human (His) YB-1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; nuclease-sensitive element-binding protein 1; Y-box transcription factor	Human	E. coli
	YBX1 Protein, Human (His) is the recombinant human-derived YBX1 protein, expressed by E. coli, with C-6*His tag.

HY-P702822

	YBX1 Protein, Mouse (P.pastoris, His) Ybx1; Msy-1; Msy1; Nsep1; Yb1; Y-box-binding protein 1; YB-1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; nuclease-sensitive element-binding protein 1; Y-box transcription factor	Mouse	P. pastoris
	YBX1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived YBX1, expressed by P. pastoris , with N-6*His labeled tag. ,

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Source
Tag
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Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (3) Rat (2) Mouse (2) Escherichia coli (1)
Application:	IHC-P (1) ICC/IF (2) IP (1) WB (4) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (4)
Clonality:	Polyclonal (1) Monoclonal (3) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87059

	RecA Antibody (YA6752) DNA strand exchange and recombination protein with protease and nuclease activity antibody; lexB antibody; Protein recA antibody; recH antibody; Recombinase A antibody;	WB, ICC/IF	Escherichia coli
	RecA Antibody (YA6752) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RecA.

HY-P85400

	SND1/P100 Antibody (YA5092) SND1; TDRD11; Staphylococcal nuclease domain-containing protein 1; 100 kDa coactivator; EBNA2 coactivator p100; Tudor domain-containing protein 11; p100 co-activator	WB, ELISA	Human
	SND1/P100 Antibody (YA5092) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SND1/P100.

HY-P82375

	APE1 Antibody (YA2120) APEX1; APE; APE1; APEX; APX; HAP1; REF1; DNA-(apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1	WB	Human, Mouse, Rat
	APE1 Antibody (YA2120) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APE1.

HY-P80936

	YB1 Antibody 1 Publications Verification YBX1; NSEP1; YB1; nuclease-sensitive element-binding protein 1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB-	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	YB1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to YB1.

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Cat. No.	Product Name		Classification

HY-21997

DMT-2'fluoro-da(bz) amidite		Phosphoramidites Adenine
DMT-2'fluoro-da(bz) amidite is a key intermediate for synthesizing antisense oligonucleotides with high nuclease resistance, high RNA binding affinity, and maintained base-pair specificity .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G		Nucleoside Analogs Guanosine
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. 2'-O,4'-C-Methyleneguanosine is a substrate for KOD DNA polymerase, which incorporates LNA-G nucleotides into growing DNA strands, including consecutive incorporations , to generate full-length extension products .

HY-W440823A

DSPE-PEG1000-Amine ammonium DSPE-PEG1000-NH2 ammonium		Pegylated Lipids
DSPE-PEG1000-Amine (DSPE-PEG1000-NH2) ammonium is a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol conjugate with a terminal amino group. DSPE-PEG1000-Amine ammonium can functionalize the surface of PLGA-lecithin-PEG core-shell nanoparticles to introduce positive surface charges. The amino group of DSPE-PEG1000-Amine ammonium can be converted into an aromatic aldehyde to react with the acetone-protected aromatic hydrazide on the surface of bovine carbonic anhydrase (BCA) molecules .

HY-173189A

2-5A pentasodium solution (100 mM) 2′,5′-ApApA pentasodium; 2′,5′-trioligoadenylate pentasodium; 5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine pentasodium		Nucleotide Analogs Adenine Nucleotide
2-5A (2′,5′-ApApA) pentasodium solution 100 mM is a high-affinity (K_a=0.04 nM) RNase L binder. 2-5A pentasodium solution 100 mM activates the nuclease activity of latent RNase L to cleave single-stranded RNA by inducing conformational changes and dimerization of latent RNase L, thereby mediating critical antiviral responses and enhancing interferon effects. 2-5A pentasodium solution 100 mM not only effectively inhibits Rauscher murine leukemia virus replication, reduces viremia and splenomegaly, but also enhances antileukemic efficacy when combined with amphotericin B and exhibits favorable high-dose tolerance. 2-5A pentasodium solution 100 mM is an important tool molecule for investigating the pathological mechanisms of viral infection, hereditary prostate cancer and leukemia .

HY-160053

Gint4.T aptamer sodium		Aptamers
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .

HY-155887

DSPE-PEG-Amine, MW 3400 ammonium DSPE-PEG-NH2, MW 3400 ammonium		Pegylated Lipids
DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research .

HY-21286

N2-Isobutyryl-2'-O-methylguanosine		Nucleoside Analogs Guanosine
N2-Isobutyryl-2'-O-methylguanosine is a nucleic acid synthesis intermediate (e.g., used in antisense oligonucleotides, mRNA modification), for example, it is a key monomer for the synthesis of 2'-O-methyl oligoribonucleotides. N2-Isobutyryl-2'-O-methylguanosine enables the final product to form stable double strands with complementary RNA and is not easily degraded by nucleases. N2-Isobutyryl-2'-O-methylguanosine is mainly used in molecular biology research, and can be used to prepare RNA hybridization probes or participate in related biochemical research such as pre-mRNA splicing mechanisms .

HY-W073825

N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine		Nucleoside Analogs Guanosine
N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a 2’-0-(2-methoxyethyl) guanosine derivative. 2’-0-methoxyethyl nucleoside derivatives can enhance the affinity with RNA and increase the resistance of oligonucleotides to nucleases.

HY-W115309

DMT-2'-F-iBu-G 5'-DMT-2'-F-ibu-dG		Phosphoramidites Guanine
DMT-2'-F-iBu-G (5'-DMT-2'-F-ibu-dG) is a modified oligonucleotide. 2'-deoxy-2'-fluoro-modified oligonucleotides shows high nuclease resistant and retained exceptional binding affinity to the RNA targets .

HY-174794

Cas9-T2A-GFP mRNA		mRNA Gene Editing
The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments.

HY-174793

Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP)		mRNA Gene Editing
The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments. The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.

HY-185053

Cas12a mRNA		mRNA
Cas12a mRNA encodes the Cas12a protein. Cas12a is a nuclease .

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