2379405-61-3
2379405-61-3
Chemical Structure
MU147
- CAS No.: 2379405-61-3
- Formula:C19H13N3O3S
- Molecular Weight:363.39
SMILES: OC1=CC(/C=C(C#N)/C(NC2=NC(C3=CC=CC=C3)=CS2)=O)=CC=C1O
Biological Activity: MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MU147 | 99.35% | MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
