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Cat. No.: HY-137786

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EGFR-IN-16

EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC₅₀ of 4.85 and 4.74 for EGFR and HER-2, respectively.

For research use only. We do not sell to patients.

CAS No.: 133550-22-8
Formula: C₁₆H₁₁NO₃
Molecular Weight:265.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EGFR-IN-16 Chemical Structure

CAS No.: 133550-22-8

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC₅₀ of 4.85 and 4.74 for EGFR and HER-2, respectively^[1].

IC₅₀ & Target^[1]

EGFR

4.85 (pIC₅₀)

HER2

4.74 (pIC₅₀)

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	1 μM Compound: 144	Inhibition of EGFR in human A431 cells Inhibition of EGFR in human A431 cells	[PMID: 1479375]

Chemical Information

CAS No. 133550-22-8
Molecular Weight 265.26
Formula C₁₆H₁₁NO₃
SMILES

O=C(C1=CC=CC=C1)/C(C#N)=C/C(C=C2)=CC(O)=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kamath S, et al. Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003;46(22):4657-4668. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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EGFR-IN-16

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR-IN-16 Related Classifications

HY-137786 Related Classifications