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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

protease activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ClpP (9) HCV Protease (24) HIV Protease (67) Protease Activated Receptor (PAR) (7) Ser/Thr Protease (25) TMPRSS6 (1) Virus Protease (64) Adrenergic Receptor (2) Akt (6) AMPK (1) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (1) APC (2) Apoptosis (47) Atg4 (2) Aurora Kinase (4) Autophagy (6) Bacterial (26) Bcl-2 Family (1) Biochemical Assay Reagents (15) c-Myc (2) Cadherin (1) Calcium Channel (7) Carbonic Anhydrase (1) Carboxypeptidase (1) Caspase (6) Cathepsin (17) CDK (1) Ceramidase (2) CHIKV (2) COX (6) Cytochrome P450 (2) Dengue Virus (9) Deubiquitinase (9) Dipeptidyl Peptidase (3) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (2) DNA/RNA Synthesis (7) Dopamine β-hydroxylase (2) Drug Derivative (2) Drug Intermediate (7) Drug Isomer (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (3) EBV (1) Elastase (7) Endogenous Metabolite (13) Endonuclease (3) Enterovirus (1) Environmental Pollutants (1) Epigenetic Reader Domain (2) ERK (4) FAAH (2) Factor VIIa (1) Factor Xa (5) FAP (3) Flavivirus (12) Fluorescent Dye (35) Free Fatty Acid Receptor (2) Fungal (4) G-quadruplex (2) Glucocorticoid Receptor (2) GLUT (1) Glutathione Peroxidase (3) HCV (15) HDAC (1) Heme Oxygenase (HO) (1) Hepcidin (1) Histone Demethylase (2) HIV (42) HSV (5) IAP (1) IFNAR (1) IGF-1R (1) Indoleamine 2,3-Dioxygenase (IDO) (4) Influenza Virus (1) Insecticide (1) Insulin Receptor (1) Interleukin Related (13) Isotope-Labeled Compounds (10) JAK (1) JNK (10) Kallikrein (1) Keap1-Nrf2 (2) Kisspeptin Receptor (1) Lipase (1) mAChR (4) MALT1 (5) MARCKS (1) MDM-2/p53 (2) Mitochondrial Metabolism (3) Mitophagy (2) MMP (10) mRNA (1) mTOR (2) NF-κB (5) NO Synthase (8) Nucleoside Antimetabolite/Analog (2) P-glycoprotein (1) p38 MAPK (9) Parasite (9) PARP (2) PD-1/PD-L1 (1) PGE synthase (1) Phosphatase (3) PI3K (5) PIKfyve (1) PKC (3) Plasminogen/Plasmin (1) Potassium Channel (2) Prion Protein (1) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (2) PROTACs (6) Proteasome (9) Reactive Oxygen Species (ROS) (17) Reference Standards (30) Renin (2) Reverse Transcriptase (1) RIP kinase (1) SARS-CoV (95) Sirtuin (1) Src (2) STAT (1) Succinate Receptor 1 (1) Syk (1) TGF-beta/Smad (3) Thrombin (5) TNF Receptor (3) Toll-like Receptor (TLR) (7) Topoisomerase (1) TREM receptor (1) TRP Channel (2) VEGFR (2) Wnt (1) β-catenin (1) γ-secretase (1)
By Research Areas:	Cancer (82) Cardiovascular Disease (37) Endocrinology (8) Infection (230) Inflammation/Immunology (89) Metabolic Disease (22) Neurological Disease (25)
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406

Inhibitors & Agonists

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Targets Recommended: Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) ClpP TMPRSS6 Calpain Serpin Enteropeptidase Ser/Thr Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18234A

Leupeptin hemisulfate Maximum Cited Publications 61 Publications Verification	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-B0182

Carmofur 5+ Cited Publications HCFU	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-N2360

Hinokiflavone 5+ Cited Publications	E1/E2/E3 Enzyme Apoptosis MMP ClpP	Infection Inflammation/Immunology Cancer
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-15148

Tipranavir 10+ Cited Publications PNU-140690	HIV Protease HIV SARS-CoV	Infection
Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-108910B

TLCK-treated Chymotrypsin 1 Publications Verification	Ser/Thr Protease	Others
TLCK-treated Chymotrypsin is a serine protease. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids. TLCK treated to inactivate residual tryspin activity .

HY-137784

Boc-Val-Pro-Arg-AMC hydrochloride	Fluorescent Dye	Others
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .

HY-125169

NSC 185058	Autophagy Atg4	Cancer
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity .

HY-P2295

Dabcyl-KTSAVLQSGFRKME-Edans TFA 2 Publications Verification	SARS-CoV	Others
Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .

HY-P4326

Boc-Val-Pro-Arg-AMC	Fluorescent Dye	Others
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-N10420

Hinokinin 1 Publications Verification	HIV Protease	Infection
Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-148073

MeO-Succ-Arg-Pro-Tyr-AMC TFA	Fluorescent Dye Ser/Thr Protease	Others
MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity . (measured at 460 nm)

HY-126034

3,4-Dichloroisocoumarin	Ser/Thr Protease Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
3,4-Dichloroisocoumarin is a potent *serine-protease* and SrLip inhibitor (K_i for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms .

HY-137840

Hippuryl-L-phenylalanine	Carboxypeptidase	Cancer
Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity .

HY-P4284

Z-GGF-CMK	Proteasome ClpP Bacterial	Infection
Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC₅₀ of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC₅₀ of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis .

HY-P2065

Ac-VEID-AMC	Fluorescent Dye	Others
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-15256

Faldaprevir BI 201335	HCV Protease	Infection
Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with K_i values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC₅₀ values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection .

HY-18234C

Leupeptin Ac-LL hydrochloride	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Leupeptin Ac-LL (hydrochloride) is the hydrochloride form of Leupeptin Ac-LL (HY-18234B). Leupeptin Ac-LL (hydrochloride) has better inhibition than Leupeptin Ac-LL .

HY-P4349A

Pyr-Arg-Thr-Lys-Arg-AMC TFA	Thrombin	Others
Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-129867

Z-Leu-Leu-Leu-AMC Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .

HY-N9528

Lyciumin A	Angiotensin-converting Enzyme (ACE) Renin	Cardiovascular Disease
Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension .

HY-P3153

Cathepsin K 1 Publications Verification	Cathepsin	Metabolic Disease
Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K induces degradation of bone collagen and can be used for the research of osteoporosis .

HY-N0556

Isoescin IA	HIV Protease	Infection
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N9366

Tumulosic acid 1 Publications Verification	Others	Inflammation/Immunology
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC₅₀= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM .

HY-163109

Carbonic anhydrase inhibitor 16	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (K_i: 28.5 nM, 2.2 nM) .

HY-P4582

Suc-Phe-Ala-Ala-Phe-pNA Suc-FAAF-pNA	Ser/Thr Protease	Others
Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a chromogenic polypeptide substrate that can be used for the quantitative activity assay of intracellular subtilisin (ISP) and neutral metalloprotease (NPS) derived from Saccharomonospora canescens. Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the catalytic triad of mature proteases to release the chromophore pNA. Suc-Phe-Ala-Ala-Phe-pNA is applicable to enzymological studies .

HY-137872

L-Leucyl-4-nitroanilide hydrochloride	Biochemical Assay Reagents	Others
L-Leucyl-4-nitroanilide hydrochloride is a commonly used substrate in various biochemical assays to measure the activity of enzymes that cleave peptide bonds, such as proteases. L-Leucine p-nitroanilide hydrochloride has unique chemical properties that allow it to be cleaved by these enzymes to form a yellow product called p-nitroaniline. This makes it a useful tool for detecting and quantifying protease activity in biological samples such as blood or tissue extracts.

HY-P2750

Cathepsin D 1 Publications Verification CTSD	Biochemical Assay Reagents	Cardiovascular Disease Neurological Disease Cancer
Cathepsin D (CTSD) is a lysosomal aspartic protease encoded by the CTSD gene. Cathepsin D regulates lysosomal protease activity. Loss of Cathepsin D leads to lysosomal dysfunction and the accumulation of various cellular proteins associated with neurodegenerative diseases. Cathepsin D is involved in breast cancer metastasis. Cathepsin D can be used in research on diseases such as breast cancer and stroke .

HY-N4155

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid	EBV HIV Protease HSV	Infection Cancer
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .

HY-P3948

Fluorescent Substrate for Pro-Specific Proteases	Fluorescent Dye	Others
Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .

HY-E70531

Collagenase/Neutral protease 2 (animal free)	Biochemical Assay Reagents	Others
Collagenase/Neutral protease 2 (animal free) is an animal-free mixture of collagenase and neutral protease that can be used for stem cell and other primary cell isolation and bioprocessing applications without the introduction of potential animal-borne pathogens. It has higher casein activity than Collagenase/Neutral Protease 1 (animal free).

HY-P10355

Succinimide-AFK-AMC acetate	Bacterial	Infection
Succinimide-AFK-AMC acetate is a marker for P. aeruginosa protease activity using cultured reference strains .

HY-P4496

Tos-Gly-Pro-Lys-pNA	Phosphatase	Others
Tos-Gly-Pro-Lys-pNA is a substrate for the serine protease ALP and can be used to measure the activity of this enzyme .

HY-P3947

Fluorescent Substrate for Subtillsin	Ser/Thr Protease	Infection
Fluorescent Substrate for Subtillsin can be used to detect the enzyme activity of subtillsin. Subtilisin is a bacterial serine protease .

HY-P11302

DABCYL-RAGGYIFS-(E-EDANS)-NH2	CHIKV Virus Protease	Infection
DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity .

HY-P4658

H-Val-Ala-pNA	Dipeptidyl Peptidase	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

HY-148310

Flaviviruses-IN-2	Virus Protease	Infection
Flaviviruses-IN-2 (compound 78) is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces the WNV (West Nile virus) *protease* activity, with inhibition of 56% .

HY-147650

HIV-1 protease-IN-5	HIV Protease	Infection
HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC₅₀ of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants .

HY-18234B

Leupeptin Ac-LL	Ser/Thr Protease	Metabolic Disease Inflammation/Immunology Cancer
Leupeptin Ac-LL is a *protease* inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity .

HY-N10420R

Hinokinin (Standard) (-)-Hinokinin (Standard)	Reference Standards HIV Protease	Infection
Hinokinin (Standard) is the analytical standard of Hinokinin. This product is intended for research and analytical applications. Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-144688

HIV-1 protease-IN-1	HIV	Infection
HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC₅₀ of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC₅₀ value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC₅₀ value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC₅₀ value of 8.23 nM against C-HIV strain Indie ^[1].

HY-P4443

Ac-GAK-AMC	Fluorescent Dye	Others
Ac-GAK-AMC is a fluorescent substrate that can be used to measure protease activity. AMC (7-amino-4-methylcoumarin) is a fluorescent group. In the presence of protease, the protease will hydrolyze Ac-GAK-AMC into a fluorescent product .

HY-18234AR

Leupeptin hemisulfate (Standard)	Reference Standards Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

HY-106920

Kynostatin 272 KNI 272; Kynostatin; NSC 651714	HIV Protease	Infection
Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS .

HY-P4349

Pyr-Arg-Thr-Lys-Arg-AMC	Thrombin	Others
Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-150549

HIV-1 protease-IN-6	HIV Protease HIV	Infection Inflammation/Immunology
HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC₅₀ of 21 pM and a K_i of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus .

HY-N2360R

Hinokiflavone (Standard)	Reference Standards E1/E2/E3 Enzyme Apoptosis MMP ClpP	Infection Inflammation/Immunology Cancer
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-126973

BI-1230	HCV Protease	Infection
BI-1230, a chemical probe, is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity .

HY-137798

Chromozym PL	Fluorescent Dye	Others
Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated .

HY-179013

NS2B/NS3-IN-9	Virus Protease Flavivirus Dengue Virus	Infection
NS2B/NS3-IN-9 (Compound 73) is a broad-spectrum, non-competitive anti-Orthoflavivirus lipopeptide inhibitor targeting the NS2B-NS3 protease. NS2B/NS3-IN-9 exhibits IC₅₀ values for Dengue virus DENV2 NS2B-NS3, West Nile virus WNV NS2B-NS3, and Zika virus ZIKV NS2B-NS3 of 2.4, 7.2, and 1.9 μM, respectively. NS2B/NS3-IN-9 also exhibits antiviral activity at the cellular level against DENV2, WNV, and ZIKV, with EC₅₀ values of 4.1, 4.9, and 5.0 μM, respectively. NS2B/NS3-IN-9 has no significant toxicity to cells. NS2B/NS3-IN-9 can be used for the study of anti-Orthoflavivirus .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18234A

Leupeptin hemisulfate Maximum Cited Publications 61 Publications Verification	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-13765

6-Thioguanine 10+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	Infection Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-N2360

Hinokiflavone 5+ Cited Publications	Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-N1992

Theaflavin 3,3'-digallate 5+ Cited Publications TF-3; ZP10	Infection Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N0110

Palmatine chloride 5+ Cited Publications	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0330

Momordin Ic 5 Publications Verification	Kochia scoparia L. Schrad. Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Chenopodiaceae Source Classification Cancer	Apoptosis Autophagy PI3K c-Myc
Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-13512

Camostat mesylate 40+ Cited Publications Camostat mesilate; FOY305; FOY-S980	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Ser/Thr Protease SARS-CoV
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-P2970

Stem bromelain	Ananas comosus(L.) Merr. Structural Classification Natural Products Classification of Application Fields Bromeliaceae Plants Inflammation/Immunology Disease Research Fields Cancer	Apoptosis PARP Caspase Bcl-2 Family Bacterial Interleukin Related
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning .

HY-N1181

Tamarixetin 2 Publications Verification 4'-O-Methyl Quercetin	Flavonols Structural Classification Classification of Application Fields Tamarix chinensis Lour. Plants Endogenous metabolite Flavonoids Tamaricaceae Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS)
Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

HY-128483

Fusaric acid	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-78726

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate HIV HIV Protease
Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-N1739

Tectoquinone 1 Publications Verification 2-Methylanthraquinone	Quinones Structural Classification Clausena heptaphylla (Roxb.) Wight & Arn. Anthraquinones Rutaceae Plants Source Classification	Environmental Pollutants DNA Alkylator/Crosslinker SARS-CoV Virus Protease
Tectoquinone (2-Methylanthraquinone) is an inhibitor for SARS CoV-2 major protease (SARS CoV-2 Mpro). Tectoquinone exhibits anti-termite and antiviral activities .

HY-N0886

Aloin B 3 Publications Verification Isobarbaloin	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Other Diseases Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Source Classification	SARS-CoV Virus Protease
Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC₅₀ of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation .

HY-N0110A

Palmatine	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N12586

Pheophytin a	Suaeda vermiculata Forssk. ex J.F.Gmel. Structural Classification Alkaloids Other Alkaloids Amaranthaceae Plants Source Classification	ERK Reactive Oxygen Species (ROS) COX PGE synthase STAT HCV HCV Protease
Pheophytin a is a multi-target inhibitor, anticancer agent, antioxidant and antiviral agent. Pheophytin a directly binds to and inhibits HCV-NS3/4A protease (IC₅₀=0.89 μM) to block viral replication. Pheophytin a also scavenges free radicals, reduces ferric ions, and exhibits cytotoxic activity against breast cancer cells. Pheophytin a effectively inhibits LPS-induced production of nitric oxide, prostaglandin E2, NOS2 and COX-2, as well as various pro-inflammatory cytokines, by downregulating the transcription levels of inflammatory mediators and blocking the ERK1/2 and STAT-1 pathways. In a low nerve growth factor environment, Pheophytin a also enhances ERK1/2 phosphorylation and synergistically promotes neurite outgrowth through MAPK pathway. Pheophytin a can be used to investigate the pathogenic mechanisms of diseases including chronic hepatitis C, sepsis, breast cancer and Alzheimer's disease .

HY-17431

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-N1941

Isosinensetin	Flavonoids other families Classification of Application Fields Flavones Plants Inflammation/Immunology Disease Research Fields Source Classification	P-glycoprotein Bacterial HIV Protease Phosphatase Reactive Oxygen Species (ROS) NF-κB p38 MAPK ERK JNK Calcium Channel
Isosinensetin is a flavonoid compound and an inhibitor of HIV-1 protease and PTP1B (IC₅₀: 2.61 µM; K_i: 0.92 µM). Isosinensetin inhibits P-glycoprotein (P-gp) in MDR1-MDCKII cells. Isosinensetin has multiple activities such as anti-tumor, anti-viral, anti-inflammatory, and antioxidant effects. Isosinensetin can be used in the research of various diseases including cancer, inflammation, osteoporosis, diabetes, etc .

HY-N10420

Hinokinin 1 Publications Verification	Arnica chamissonis Less. Infection Acanthaceae Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	HIV Protease
Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-126034

3,4-Dichloroisocoumarin	Animals Coumarins Phenylpropanoids Source Classification	Ser/Thr Protease Apoptosis
3,4-Dichloroisocoumarin is a potent *serine-protease* and SrLip inhibitor (K_i for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms .

HY-N1910

4'-O-Methylbavachalcone 4 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	SARS-CoV Virus Protease Succinate Receptor 1 ERK
4'-O-Methylbavachalcone is an orally active prenylated flavonoid that inhibits the activity of *SARS-CoV papain-like protease* (PLpro), with an IC₅₀ of 10.1 μM and a K_i of 4.6 μM. 4'-O-Methylbavachalcone inhibits poly (ADP-ribose) polymerase-mediated cell death (parthanatos), reduces cerebral infarct volume, binds to the orthosteric site of SUCNR1, blocks the interaction between succinate and SUCNR1, inhibits SUCNR1** activity, blocks the nuclear translocation of NFATc4, suppresses the activation of the ERK1/2 signaling pathway, inhibits cardiomyocyte hypertrophy and restores the expression of α-actinin. 4'-O-Methylbavachalcone can be used in studies related to ischemic stroke, SARS-CoV and cardiomyocyte hypertrophy .

HY-W012572

D-Histidine	Microorganisms Source Classification	Mitochondrial Metabolism Bacterial
D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-N2996

Ganodermanondiol	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-13765R

6-Thioguanine (Standard) Thioguanine (Standard); 2-Amino-6-purinethiol (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-N0110B

Palmatine hydroxide 5+ Cited Publications	Alkaloids Phellodendron amurense Rupr. Other Alkaloids Rutaceae Plants Source Classification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0857

Deoxyandrographolide 1 Publications Verification	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	GLUT HDAC Virus Protease PI3K AMPK Akt Histone Demethylase MDM-2/p53 IFNAR Reactive Oxygen Species (ROS)
Deoxyandrographolide is an orally active lactone found in the Andrographis paniculata Nees. Deoxyandrographolide shows a K_D of 38.4 μM of HDAC1. Deoxyandrographolide enhances GLUT4 plasma membrane translocation, activates PI3K and AMPK-dependent signaling pathways, suppresses fasting blood glucose, serum insulin, triglycerides, and LDL-cholesterol levels. Deoxyandrographolide enhances HDAC1 expression via inhibited ubiquitination degradation, represses H3K4me3, improves chromosome stability, and restrains aging biomarkers p16, p21, γH2A.X, p53 and ROS production. Deoxyandrographolide interacts with Foot-and-Mouth Disease Virus 3Cpro active site, inhibits *protease* and IFN-antagonist activity, derepresses ISG expression, and inhibits viral replication. Deoxyandrographolide can be used for the researches of type 2 diabetes mellitus, vascular senescence and virus infection .

HY-18234C

Leupeptin Ac-LL hydrochloride	Natural Products Microorganisms Source Classification	Biochemical Assay Reagents
Leupeptin Ac-LL (hydrochloride) is the hydrochloride form of Leupeptin Ac-LL (HY-18234B). Leupeptin Ac-LL (hydrochloride) has better inhibition than Leupeptin Ac-LL .

HY-N9528

Lyciumin A	Cardiovascular Disease Alkaloids Monophenols Pyrrole Alkaloids Classification of Application Fields Phenols Plants Solanaceae Lycium chinense Miller Disease Research Fields Indole Alkaloids Source Classification	Angiotensin-converting Enzyme (ACE) Renin
Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension .

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Plants Disease Research Fields Source Classification	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N9366

Tumulosic acid 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC₅₀= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM .

HY-13512R

Camostat mesylate (Standard) Camostat mesilate (Standard); FOY305 (Standard); FOY-S980 (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Ser/Thr Protease SARS-CoV
Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-N4155

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid	Rosaceae Rosa cymosa (L.) Tratt. Plants	EBV HIV Protease HSV
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .

HY-N1181R

Tamarixetin (Standard) 4'-O-Methyl Quercetin (Standard)	Flavonols Structural Classification Flavonoids Tamaricaceae Tamarix chinensis Lour. Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species (ROS)
Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

HY-N10420R

Hinokinin (Standard) (-)-Hinokinin (Standard)	Arnica chamissonis Less. Acanthaceae Lignans Phenylpropanoids Plants Source Classification	Reference Standards HIV Protease
Hinokinin (Standard) is the analytical standard of Hinokinin. This product is intended for research and analytical applications. Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-18234AR

Leupeptin hemisulfate (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Cathepsin Ser/Thr Protease Virus Protease
Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

HY-N2360R

Hinokiflavone (Standard)	Structural Classification Flavonoids Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Source Classification	Reference Standards E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-N8471

Niazinin	Natural Products Classification of Application Fields Moringa oleifera Lam. Moringaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Parasite SARS-CoV
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC₅₀ value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity .

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Source Classification	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .

HY-100397

Elastatinal	Source Classification	Elastase
Elastatinal is a potent and competitive inhibitor of elastase, with a K_i of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease .

HY-N0556R

Isoescin IA (Standard)	Other Terpenoids Aesculus chinensis Bunge Structural Classification Terpenoids Hippocastanaceae Plants Source Classification	Reference Standards HIV Protease
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N1739R

Tectoquinone (Standard) 2-Methylanthraquinone (Standard)	Quinones Structural Classification Clausena heptaphylla (Roxb.) Wight & Arn. Anthraquinones Rutaceae Plants Source Classification	Reference Standards SARS-CoV Virus Protease
Tectoquinone (Standard) is the analytical standard of Tectoquinone. This product is intended for research and analytical applications. Tectoquinone (2-Methylanthraquinone) is an inhibitor for SARS CoV-2 major protease (SARS CoV-2 Mpro). Tectoquinone exhibits anti-termite and antiviral activities .

HY-N1992R

Theaflavin 3,3'-digallate (Standard) TF-3 (Standard); ZP10 (Standard)	Structural Classification Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N0554R

Escin IA (Standard)	Triterpenes Structural Classification other families Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Source Classification	Reference Standards HIV Protease
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N0110R

Palmatine chloride (Standard)	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR Reference Standards
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N8693

Withanoside IV	Structural Classification Withania somnifera Solanaceae Plants Steroids Source Classification	COX Amyloid-β Sirtuin Reactive Oxygen Species (ROS) Apoptosis SARS-CoV
Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19) .

HY-N14772

Laccaridione A	Quinones Microorganisms Naphthalene Quinones Source Classification	Ser/Thr Protease
Laccaridione A can inhibit the activity of antiserine protease. Laccaridione A inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC₅₀s of 14.7 μg/mL, 2.5 μg/mL, 18.8 μg/mL, 7.2 μg/mL and 18.2 μg/mL, respectively .

HY-N5185

Cyclothiazomycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity .

HY-N10934

Ganoderic acid GS-1	Triterpenes Microorganisms Terpenoids Source Classification	HIV Protease
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM .

HY-N11940

Acetyl-binankadsurin A	Lignans Phenylpropanoids Plants Schisandraceae Kadsura longipedunculata Finet et Gagnep. Source Classification	HIV Protease
Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A has low inhibitory activity against HIV-1 protease, with IC₅₀ >100 μg/mL .

HY-N15009

Kynapcin-13	Natural Products Microorganisms Source Classification	Prolyl Endopeptidase (PREP)
Kynapcin-13 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC₅₀ of 76.80 μM. Kynapcin-13 has a little inhibitory effect on other serine proteases .

HY-N15010

Kynapcin-28	Microorganisms Antibiotics Other Antibiotics Source Classification	Prolyl Endopeptidase (PREP)
Kynapcin-28 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC₅₀ of 76.80 μM. Kynapcin-28 has a little inhibitory effect on other serine proteases .

Cat. No.	Product Name	Chemical Structure

HY-78726S

Fosamprenavir-d4

Fosamprenavir-d₄ is the Deuterium-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-10235S

Telaprevir-d4
Telaprevir-d₄ is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide . Telaprevir inhibits SARS-CoV-2 3CLpro activity .

HY-17007S

Saquinavir-d9
Saquinavir-d₉ (Ro 31-8959-d₉) is the deuterium labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

HY-15148S1

Tipranavir-d7
Tipranavir-d₇ is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .

HY-78726S2

Fosamprenavir-13C6

Fosamprenavir- ¹³C₆ is the ¹³C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-17007S2

Saquinavir-13C6
Saquinavir- ¹³C₆ (Ro 31-8959- ¹³C₆) is ¹³C labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .

HY-10237S

Boceprevir-d9
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a K_i of 14 nM in both enzyme assay and an EC₉₀ of 350 nM in cell-based replicon assay . Boceprevir inhibits SARS-CoV-2 3CLpro activity .

HY-W027544S

MCA-d3
MCA-d₃ (7-Methoxycoumarin-4-acetic acid₃) is the deuterium labeled MCA (HY-W027544) . MCA is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .

HY-B0689S1

Indinavir-13C4,15N

Indinavir- ¹³C₄, ¹⁵N (MK-639 (free base)- ¹³C₄, ¹⁵N) is ¹³C and ¹⁵N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

HY-W653745

6-Thioguanine-13C2,15N
6-Thioguanine-13C2,15N (Thioguanine-13C2,15N) is the ¹³C and ¹⁵N labeled 6-Thioguanine (HY-13765). 6-Thioguanine is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Targets Recommended: Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) ClpP TMPRSS6 Calpain Serpin Enteropeptidase Ser/Thr Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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