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Results for "

rapidly metabolize

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Apoptosis (2) Aryl Hydrocarbon Receptor (1) Bacterial (2) Biochemical Assay Reagents (1) Cannabinoid Receptor (1) Cholinesterase (ChE) (1) Complement System (1) Cytochrome P450 (2) Drug Derivative (2) Drug Metabolite (4) Fluorescent Dye (1) Fungal (1) Glucocorticoid Receptor (1) GnRH Receptor (1) HBV (1) Interleukin Related (2) Reference Standards (3) TNF Receptor (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Infection (4) Inflammation/Immunology (4) Metabolic Disease (8) Neurological Disease (4)

By Targets:

Adrenergic Receptor (1)

Apoptosis (2)

Aryl Hydrocarbon Receptor (1)

Bacterial (2)

Biochemical Assay Reagents (1)

Cannabinoid Receptor (1)

Cholinesterase (ChE) (1)

Complement System (1)

Cytochrome P450 (2)

Drug Derivative (2)

Drug Metabolite (4)

Fluorescent Dye (1)

Fungal (1)

Glucocorticoid Receptor (1)

GnRH Receptor (1)

HBV (1)

Interleukin Related (2)

Reference Standards (3)

TNF Receptor (2)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (3)

Cardiovascular Disease (3)

Infection (4)

Inflammation/Immunology (4)

Metabolic Disease (8)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011404

Tributyrin 1 Publications Verification Glyceryl tributyrate	Apoptosis TNF Receptor Interleukin Related	Metabolic Disease Cancer
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects .

HY-B1069

Molsidomine 1 Publications Verification SIN-10; Morsydomine	Drug Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications .

HY-G0006

Omeprazole sulfide 2 Publications Verification Ufiprazole	Drug Metabolite Aryl Hydrocarbon Receptor Bacterial	Infection Metabolic Disease
Omeprazole sulfide (Ufiprazole) is a metabolic degradation product of Omeprazole (HY-B0113). Omeprazole sulfide acts as a modulator of AhR. Omeprazole sulfide in cells with low CYP3A4 expression, functions as an AhR antagonist; however, in cells with high CYP3A4 expression, it is rapidly metabolized to Omeprazole, thereby acting as an AhR agonist. Omeprazole sulfide exhibits antibacterial activity when conjugated with silver nanoparticles (AgNPs). Omeprazole sulfide can be used in research on acid suppression and bacterial infections .

HY-110207

SM-324405	Toll-like Receptor (TLR)	Inflammation/Immunology
SM-324405 is a TLR7 agonistic antedrug (EC₅₀ = 50 nM), with pEC₅₀ values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively. SM-324405 is used for immunoresearch of allergic diseases. An antedrug is defined as a locally active compound that is designed to be rapidly metabolized to an inactive form upon entry into the circulation and prevents systemic toxicity by losing its agonistic activity in a plasmatic environment .

HY-B2053

Tolclofos-methyl	Fungal	Infection
Tolclofos-methyl is an organophosphorus fungicide. Tolclofos-methyl undergoes photoinduced oxidative degradation to form oxo-analog derivatives. Tolclofos-methyl inhibits spore division in fungi and oomycetes, induces cytoplasmic leakage, and interferes with flagellar movement. Tolclofos-methyl is rapidly metabolized and excreted in rodents. Tolclofos-methyl can be used in studies related to fungal infections .

HY-W267897

7-Benzyloxy-4-(trifluoromethyl)coumarin 7-BFC	Cytochrome P450	Others
7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies .

HY-112199

CP-447697	Complement System	Inflammation/Immunology
CP-447697 is a lipophilic C5a receptor antagonist with an IC₅₀ value of 31 nM. CP-447697 can be used for the research of inflammation .

HY-112621

Leukotriene A4 methyl ester LTA4 methyl ester	Biochemical Assay Reagents	Inflammation/Immunology
Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

HY-172346

N-Hydroxy MDMA hemioxalate N-OH MDMA hemioxalate; FLEA hemioxalate	Drug Derivative	Neurological Disease Metabolic Disease
N-Hydroxy MDMA (N-OH MDMA) hemioxalate is an N-hydroxy analogue of 3,4-methylenedioxymethamphetamine (MDMA). N-Hydroxy MDMA hemioxalate can be rapidly metabolized to MDMA and MDA in rats, which are mainly excreted in urine, and can also be detected in hair .

HY-W011404R

Tributyrin (Standard) Glyceryl tributyrate (Standard)	Apoptosis Reference Standards TNF Receptor Interleukin Related	Metabolic Disease Cancer
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects .

HY-106983

GR 250495X	Glucocorticoid Receptor	Inflammation/Immunology
GR 250495X is an inhaled glucocorticoid receptor agonist. GR 250495X is designed as a antedrug, which takes effect locally in the lungs but is rapidly metabolized and inactivated in the bloodstream after entering the systemic circulation, thereby minimizing systemic side effects. GR 250495X can be used in asthma research .

HY-114663

FDU-PB-22	Cannabinoid Receptor	Others
FDU-PB-22 is a new synthetic cannabinoid that is rapidly metabolized in HLM, with a half-life of 12.4 minutes .

HY-107010

Esprolol	Adrenergic Receptor	Cardiovascular Disease
Esprolol is an orally active and potent β-adrenergic receptor antagonist. Esprolol is rapidly metabolized by blood and tissue esterases to form the active metabolite amoxolol. Esprolol holds potential for research in exercise-induced angina .

HY-14795

Mimopezil ZT-1	Cholinesterase (ChE)	Neurological Disease
Mimopezil (ZT-1) is an cholinesterase (ChE) inhibitor that rapidly degrades into the active metabolite Huperzine A (HY-17388) in water or aqueous organic solvents. After oral administration, Mimopezil is rapidly absorbed but has low bioavailability (0.37%) in rats. However, after metabolism, it is converted into Huperzine A, which accumulates in the blood and exhibits strong activity. Following intravenous administration, Mimopezil reaches higher blood concentrations and is also rapidly metabolized into Huperzine A .

HY-D1749

C6 NBD L-threo-ceramide	Fluorescent Dye	Others
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

HY-173120

HBV-IN-51	HBV	Infection
HBV-IN-51 (Compound 17e) is a potent HBV capsid assembly modulator. HBV-IN-51 exhibits remarkable anti-HBV activity with an EC₅₀ of 0.033 μM in HepAD38 cells. HBV-IN-51 exhibits robust metabolic stability in plasma, and can be rapidly metabolized in human liver microsomes .

HY-113879

18-Carboxy dinor Leukotriene B4 18-Carboxy dinor LTB4	Drug Metabolite	Metabolic Disease
18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.

HY-B1069R

Molsidomine (Standard) SIN-10 (Standard); Morsydomine (Standard)	Reference Standards Drug Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
Molsidomine (Standard) (SIN-10 (Standard)) is the analytical standard of Molsidomine (HY-B1069). This product is intended for research and analytical applications. Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications.

HY-179011

CYP3A4-IN-6	Cytochrome P450	Metabolic Disease
CYP3A4-IN-6 (Compound 8a) is a CYP3A4 inhibitor with tissue-selective metabolism. CYP3A4-IN-6 remains stable in the intestinal S9 component but is rapidly metabolized in the liver S9 component, forming a less active metabolite. CYP3A4-IN-6 can be used for intestinal selectivity studies .

HY-B2053R

Tolclofos-methyl (Standard)	Reference Standards Bacterial	Infection
Tolclofos-methyl (Standard) is the analytical standard of Tolclofos-methyl (HY-B2053). This product is intended for research and analytical applications. Tolclofos-methyl is an organophosphorus fungicide. Tolclofos-methyl undergoes photoinduced oxidative degradation to form oxo-analog derivatives. Tolclofos-methyl inhibits spore division in fungi and oomycetes, induces cytoplasmic leakage, and interferes with flagellar movement. Tolclofos-methyl is rapidly metabolized and excreted in rodents. Tolclofos-methyl can be used in studies related to fungal infections .

HY-P10490

(D-His(Bzl)6)-LHRH (1-7) free acid	Drug Derivative GnRH Receptor	Others Cancer
(D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic peptide compound that is a derivative of luteinizing hormone-releasing hormone (LHRH). (D-His(Bzl)6)-LHRH (1-7) free acid enhances its stability and biological activity by introducing unnatural amino acid residues at specific positions of the LHRH molecule. This modification can improve the drug's performance in the body half-life, reducing the rate at which it is rapidly metabolized and cleared, thereby enhancing its efficacy in inhibiting cell proliferation .

C6 NBD L-threo-ceramide	Fluorescent Dyes
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

Cat. No.	Product Name	Target	Research Area

HY-P10490

(D-His(Bzl)6)-LHRH (1-7) free acid	Drug Derivative GnRH Receptor	Others Cancer
(D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic peptide compound that is a derivative of luteinizing hormone-releasing hormone (LHRH). (D-His(Bzl)6)-LHRH (1-7) free acid enhances its stability and biological activity by introducing unnatural amino acid residues at specific positions of the LHRH molecule. This modification can improve the drug's performance in the body half-life, reducing the rate at which it is rapidly metabolized and cleared, thereby enhancing its efficacy in inhibiting cell proliferation .

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