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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
secretory proteins
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "secretory proteins" in MCE Product Catalog:
3
Research Areas:
Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets .
Cat. No.: HY-P99505
CAS No.: 2226654-05-1
Synonyms: COR-001; MEDI-5117; MEDI-5117; NN-6018; WBP-216
Target:
Research Areas:
Cat. No.: HY-16498
CAS No.: 848084-83-3
Synonyms: PCK-3145
Research Areas:
Cat. No.: HY-176130
CAS No.: 3115333-82-6
Target:
Research Areas:
MRL828 is a heterobifunctional molecule that targets aggregated tau protein. As an autophagy-targeting chimera (ATTEC), MRL828 selectively labels aggregated tau protein for clearance via the autophagy (autophagy)-lysosome pathway. The activity of MRL828 depends on autophagosomes rather than lysosomes, and it induces autophagosome-dependent secretion. MRL828 acts as an intracellular aggregate inhibitor and a secretory autophagy inducer, reducing intracellular levels of aggregated tau protein through autophagosome-dependent secretory autophagy instead of lysosomal degradation. MRL828 can be used in the research of neurodegenerative diseases such as Alzheimer's disease .
Cat. No.: HY-401913
CAS No.: 345288-49-5
Target:
Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM). Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model .
Cat. No.: HY-164186
Target:
Research Areas:
M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.
Cat. No.: HY-169948
CAS No.: 183321-62-2
BML-265 is a potent EGFR tyrosine kinase inhibitor. BML-265 disrupts Golgi integrity and abolishes secretory protein transport of diverse cargos. BML-265 affects Golgi integrity and transport in human cells but not in rodent cells .
Cat. No.: HY-P5370
CAS No.: 1678415-68-3
Cat. No.: HY-P3600
Target:
Research Areas:
Cat. No.: HY-175302
CAS No.: 3044124-79-7
Target:
Research Areas:
TRK-IN-32 is a potent TRK inhibitor. TRK-IN-32 potently inhibits TRK WT, TRK G595R and TRK G667C with IC50 values of 0.08 nM, 2.14 nM and 0.68 nM, respectively. TRK-IN-32 also demonstrates antiproliferative activity against a panel of Ba/F3 cell lines transformed with wild type, xDFG, solvent-front as well as gatekeeper mutant TRK fusion proteins. TRK-IN-32 induces apoptosis of Ba/F3-TRKA WT and Ba/F3-TRKA G667C cells.TRK-IN-32 can be used for the study of various cancers (such as thyroid cancer, secretory breast carcinoma) .
Cat. No.: HY-P3987A
Cat. No.: HY-16497
CAS No.: 848084-84-4
Synonyms: PCK 3145 TFA
Research Areas:
Tigapotide TFA (PCK-3145 TFA) is a synthetic 15-mer peptide derived from prostate-secretory protein, and acts as an antineoplastic agent. Tigapotide TFA inhibits tumor growth, experimental bone metastasis, and malignancy-associated hypocalcemia. Tigapotide TFA induces Apoptosis in prostate cancer cells and tumors, and suppresses the growth of prostate cancer cells. Tigapotide TFA inhibits the production of parathyroid hormone-related protein (PTHrP) in tumors and plasma. Tigapotide TFA reduces plasma calcium levels in hypercalcemic tumor-bearing rats. Tigapotide TFA is applicable for the research of prostate cancer and malignancy-associated hypercalcemia .
Cat. No.: HY-P10466A
Research Areas:
Cat. No.: HY-P71502
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPP4C; PPP4; Protein Phosphatase 4 Catalytic Subunit; Epididymis secretory Sperm Binding Protein; PPX; Protein Phosphatase 4, Catalytic Subunit; PP4; Serine/Threonine-Protein Phosphatase; Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit; Protein-S
Species:
E.coli
Source:
E. coli
Cat. No.: HY-P71516
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPP4C; PPP4; Protein Phosphatase 4 Catalytic Subunit; Epididymis secretory Sperm Binding Protein; PPX; Protein Phosphatase 4, Catalytic Subunit; PP4; Serine/Threonine-Protein Phosphatase; Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit; Protein-S
Species:
E.coli
Source:
E. coli
Cat. No.: HY-P10466
CAS No.: 2377734-91-1
Research Areas:
Cat. No.: HY-L212
128 compounds
Neuropeptides are small proteins produced and released by neurons through the regulation of secretory pathways, expressed in neurons and have transmitter or co-transmitter functions, and are used as nerve substrates. Neuropeptides are by far the largest and most diverse signaling molecules in the brain and have been implicated in the development of diseases and drugs. Neuropeptides are involved in inflammatory and immune diseases and have an impact on epithelial, vascular, and connective tissue cells proliferation and tissue repair. Studies have shown that neuropeptides are particularly important when the nervous system is challenged, such as stress, injury, or substance abuse. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system and is currently in clinical research and has been shown to be involved in inflammatory processes and pain.
MCE can provide 128 neuropeptides that can be used for scientific research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
