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Results for "

sialic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (1) Apoptosis (1) Bacterial (2) Beta-lactamase (1) Biochemical Assay Reagents (10) Drug Derivative (2) Endogenous Metabolite (21) Fluorescent Dye (4) Fructose-1,6-bisphosphate aldolase (2) Glycosidase (1) Glycosyltransferase (1) HBV (2) HIV (1) Influenza Virus (6) LYTACs (1) mTOR (1) Ras (2) Reference Standards (4) Ser/Thr Protease (1) Sialyltransferase (4) Small Interfering RNA (siRNA) (2) Transmembrane Glycoprotein (3) Tyrosinase (2)
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110288

3FAx-Neu5Ac 3 Publications Verification	Sialyltransferase	Metabolic Disease
3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X .

HY-112942A

*CMP-Sialic* acid sodium salt** 4 Publications Verification CMP-Neu5Ac sodium salt	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-I0400

N-Acetylneuraminic acid 5 Publications Verification NANA; Lactaminic acid	Tyrosinase Ras Influenza Virus Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

HY-128850

N-Acetyl-D-mannosamine N-Acetylmannosamine; ManNAc	Endogenous Metabolite	Cardiovascular Disease Neurological Disease
N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders .

HY-148476

Tri-GalNAc-DBCO	LYTACs	Metabolic Disease
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation .

HY-128965

N-Glycolylneuraminic acid NeuGc; GcNeu	Influenza Virus Endogenous Metabolite	Infection Cancer
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-E70024

*CMP-sialic* acid synthetase (NmCSS)**	Sialyltransferase	Others
CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases .

HY-P2988

Neuraminidase, Microorganism 1 Publications Verification Exo-α-sialidase	Endogenous Metabolite	Infection
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .

HY-E70097

Sialidase (α2-3-6-8-9)	Endogenous Metabolite	Others
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling .

HY-P991636

AK006	Transmembrane Glycoprotein	Inflammation/Immunology
AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research .

HY-112942

*CMP-Sialic* acid** CMP-Neu5Ac	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-75279

N-Acetyl-β-neuraminic acid methyl ester N-Acetyl-Neuraminic acid (sialic acid)	Drug Derivative	Others
N-Acetyl-β-neuraminic acid methyl ester (N-Acetyl-Neuraminic acid (Sialic acid)) is an ester compound .

HY-NP0149

Sambucus Nigra Lectin (Biotinylated) SNA (Biotinylated)	Biochemical Assay Reagents	Others
Sambucus Nigra Lectin (SNA) (Biotinylated) is a terminal sialic acid (SA) residue-binding lectin with biotinylation modification. Sambucus Nigra Lectin (Biotinylated) binds specifically to terminal sialic acid residues on captured IgG and its subclasses .

HY-147168

Biocytin hydrazide	Biochemical Assay Reagents	Others
Biocytin hydrazide is a long-chain biotin-containing hydrazide, serving as a biotin-derived active coupling reagent, selective labeling agent and biotinylating reagent. Biocytin hydrazide targets aldehyde, carboxyl, amino and guanidino groups to biotinylate glycoconjugates, K99 lectin, peptides and proteins through its hydrazide moiety, and achieves nonradioactive detection of sialic acid- and galactose-containing glycoconjugates via the avidin–biotin system .

HY-P2988B

Neuraminidase, arthrobacter ureafaciens	Bacterial HIV	Infection
Neuraminidase, arthrobacter ureafaciens is a neuraminidase derived from Arthrobacter ureafaciens. Neuraminidase, arthrobacter ureafaciens catalyzes the removal of sialic acid residues from cell surfaces and viral glycoconjugates. Neuraminidase, arthrobacter ureafaciens enhances HIV-1-mediated syncytium formation and promotes the viral binding and entry steps in the HIV-1 replication cycle .

HY-N12931F

Maackia amurensis Lectin (MAA/MAL II)-Biotinylated	Fluorescent Dye	Others Cancer
Maackia amurensis Lectin (MAA/MAL II)-Biotinylated is a plant lectin modified by biotin. Maackia amurensis Lectin (MAA/MAL II)-Biotinylated has the activity to recognize specific sugar structures, specifically the alpha-2, 3-linked sialic acid (HY-I0400). Maackia amurensis Lectin (MAA/MAL II)-Biotinylated has a very high affinity with avidin or streptavidin and this interaction can be used to fix it to solid surfaces or bind it to other molecules. Maackia amurensis Lectin (MAA/MAL II)-Biotinylated can be used to isolate and purify proteins or other molecules with specific sugar chain structures in affinity chromatography as well as for disease marker discovery and cancer research .

HY-NP0147

Wheat Germ Agglutinin (Fluorescein) 1 Publications Verification WGA (Fluorescein)	Fluorescent Dye	Infection Neurological Disease
Wheat Germ Agglutinin (WGA) Fluorescein is a classic fluorescent label that specifically binds to sugar residues such as N-acetylglucosamine, N-acetylneuraminic acid and sialic acid. Wheat Germ Agglutinin Fluorescein performs regionally differential fluorescent staining of the ocular surface epithelial glycocalyx to assess its integrity, and causes no damage to the eye at safe concentrations. Wheat Germ Agglutinin Fluorescein is also used for staining structures including red blood cells, cultured cells, bacteria and pine wood nematodes, and facilitates the isolation of wheat-associated plant-growth-promoting rhizobacterial strains. Wheat Germ Agglutinin Fluorescein can be applied to the detection of ocular glycocalyx integrity and the research of related diseases such as pine wilt disease .

HY-147266

Elebsiran sodium VIR-2218 sodium	Small Interfering RNA (siRNA) HBV	Infection
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .

HY-160821A

N-Acetylmannosamine 6-phosphate sodium salt ManNAc-6P sodium salt	Endogenous Metabolite	Others
N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy .

HY-D0871

CHES N-Cyclohexyltaurine	Biochemical Assay Reagents Influenza Virus	Infection
CHES (N-Cyclohexyltaurine) is a biological buffer reagent that binds to influenza virus hemagglutinin (HA). CHES mimics the binding mode of sialic acid to the HA receptor-binding site .

HY-145533

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid KDN	Biochemical Assay Reagents	Others
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a type of sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be hydrolyzed by sialidase from the loach (Misgurnus fossilis) .

HY-D1991

ATTO 647	Fluorescent Dye	Others
ATTO 647 is a carborhodamine fluorophore and imaging tracer with photostable properties. ATTO 647 serves as a fluorescent probe to investigate cell membrane structure and diffusion characteristics. When conjugated with wheat germ agglutinin, ATTO 647 specifically binds to N-acetyl-β-D-glucosamine and sialic acid residues on membrane glycoproteins, enabling single-molecule tracing of glycoprotein diffusion. ATTO 647 exhibits highly stable fluorescence properties with significantly reduced blinking in mounting media such as ROXS (AA/MV) and ROXS (TX/TQ), whereas its brightness properties vary in Ibidi-MM and Vectashield. ATTO 647 can also be used to label histone H2B-GFP in fixed cells for confocal microscopy photobleaching experiments .

HY-164390

6′SLN Neu5Acα2-6Galβ1-4GlcNAc	Endogenous Metabolite	Infection Cancer
6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .

HY-W747597

Ganglioside GD1b Disodium Salt (Bovine Brain) Disialoganglioside GD1b; Ganglioside C1; Ganglioside G2	Endogenous Metabolite	Cancer
Ganglioside GD1b Disodium Salt (Bovine Brain) (Disialoganglioside GD1b; Ganglioside C1) is an acidic glycosphingolipid containing two sialic acid residues linked to an internal galactose unit. Ganglioside GD1b Disodium Salt tightly packs with cholesterol to form lipid microdomains that modulate intracellular and intercellular signaling events. Concentrations of Ganglioside GD1b Disodium Salt (Bovine Brain) in the human brain increase with age and are positively correlated with pilocytic astrocytoma tumor grade. Ganglioside GD1b Disodium Salt has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas.

HY-P2988A

α2-3,6 Neuraminidase, Bifidobacterium infantis	Influenza Virus	Metabolic Disease
α2-3,6 Neuraminidase, Bifidobacterium infantis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal α2-3 and α2-6 unbranched sialic acid residues from complex carbohydrates and glycoproteins. α2-3,6 Neuraminidase does not exhibit activity on α2-8 or branched sialic acids .

HY-I0400R

N-Acetylneuraminic acid (Standard) NANA (Standard); Lactaminic acid (Standard)	Reference Standards Tyrosinase Ras Influenza Virus Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

HY-154790

STn/sialyl-Tn Neu5Aca2-6GalNAc-a-Ser/Thr	Ser/Thr Protease	Cancer
STn/sialyl-Tn is a sialic acid associated with breast cancer and its expression is closely related to HER2-pos. STn/sialyl-Tn can be used as a marker to count cells in malignant nipple discharge (PND) .

HY-75102

4-Boronobenzoic acid	Biochemical Assay Reagents	Cancer
4-Boronobenzoic acid is an organic compound. 4-Boronobenzoic acid forms reversible cyclic boronate esters with molecules containing cis-vicinal diol structures (such as sialic acid) through the boron atom, achieving molecular recognition and binding. 4-Boronobenzoic acid can be used in research of breast cancer .

HY-E70132

Endo-β-N-acetylglucosaminidase D Endo D	Glycosidase	Metabolic Disease
Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate .

HY-P2977

N-Acetylneuraminate lyase (CgNal) sialic acid aldolase (CgNal)	Fructose-1,6-bisphosphate aldolase Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-E70039

alpha-2-3,6,8-Sialidosidase (SpNanA)	Others	Others
alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates .

HY-147266A

Elebsiran VIR-2218	HBV Small Interfering RNA (siRNA)	Infection
Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Biochemical Assay Reagents	Others
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-E70062

α-2,3-Sialyltransferase, pasteurella multocida Fh8-PmST3	Endogenous Metabolite	Metabolic Disease
alpha-2,3-Sialyltransferase (PmST3) (EC 2.4.99.4) is a beta-galactoside. alpha-2,3-Sialyltransferase (PmST3) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-E70063

alpha-2,3-Sialyltransferase (Phα2,3SiaT)	Endogenous Metabolite	Metabolic Disease
alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-P990163

Anti-Mouse Siglec-H Antibody (440c)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis .

HY-112944A

CMP-SiaNAz sodium CMP-NeuNAz sodium	Sialyltransferase	Infection
CMP-SiaNAz (CMP-NeuNAz) sodium is a sialic acid nucleotide sugar derivative. CMP-SiaNAz sodium is integrated into the glycosidic chain through the action of STs in the Golgi apparatus, forming SiaNAz substances. CMP-SiaNAz sodium can serve as a substrate for bacterial-derived sialic acid transferases and is used for chemical enzymatic labeling and imaging of cell surface glycosides .

HY-E70287

ST6 Sialyltransferase 5 ST6GALNAC5	Glycosyltransferase	Metabolic Disease
ST6 Sialyltransferase 5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers a sialic acid to N-acetylgalactosamine (GalNAc) residues. ST6 Sialyltransferase 5 is a bio-marker in cervical screening samples .

HY-E70150

ST6 Sialyltransferase 1 EC:2.4.3.3; Alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase 1	Sialyltransferase	Cancer
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer .

HY-E70621

Sialic acid aldolase (Pm NaNa)	Biochemical Assay Reagents Fructose-1,6-bisphosphate aldolase	Metabolic Disease
Sialic acid aldolase (Pm NaNa) (EC 4.1.3.3) is a type I aldolase that catalyze the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) to form pyruvate and N-acetyl-D-mannosamine (ManNAc) with the equilibrium favoring the Neu5Ac cleavage .

HY-161160

Ac4ManNDAz	Fluorescent Dye	Others
Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .

HY-128850R

N-Acetyl-D-mannosamine (Standard) N-Acetylmannosamine (Standard); ManNAc (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease Neurological Disease
N-Acetyl-D-mannosamine (Standard) is an analytical standard for N-Acetyl-D-mannosamine. This product is intended for research and analytical applications. N-Acetyl-D-mannosamine (ManNAc) is an orally active sialic acid (Sialic Acid) precursor that can prevent hypertension by increasing sialylation of IgG and has potential for use in cardiovascular disease research. N-Acetyl-D-mannosamine activates hypocretin (HCRT) gene expression and alters

HY-E70152

ST6 Sialyltransferase 4 EC:2.4.3.7; ST6GALNAC4; SIAT3-C	Biochemical Assay Reagents	Cancer
ST6 Sialyltransferase 4 (EC:2.4.3.7; ST6GALNAC4; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. ST6 Sialyltransferase 4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation. .

HY-E70298

ST3 β-Gal α-2,3-Sialyltransferase 1 ST3GAL1	Endogenous Metabolite	Cancer
ST3 β-Gal α-2,3-Sialyltransferase 1 (ST3GAL1) is a sialyltransferase whose overexpression in ovarian cancer cell lines enhances cell growth, migration, and invasion capabilities, as well as increases tumorigenicity and resistance to paclitaxel in vivo. ST3 β-Gal α-2,3-Sialyltransferase 1 catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and can be utilized in studies of cancer progression and chemotherapy resistance .

HY-128965R

N-Glycolylneuraminic acid (Standard) NeuGc (Standard); GcNeu (Standard)	Reference Standards Influenza Virus Endogenous Metabolite	Infection Cancer
N-Glycolylneuraminic acid (Standard) is the analytical standard of N-Glycolylneuraminic acid. This product is intended for research and analytical applications. N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-145533A

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium KDN sodium	Endogenous Metabolite	Others
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) sodium is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium is abundant in fetal cord red blood cells and malignant human ovarian cancer cells .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents	Others
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

HY-105284R

Sulopenem (Standard) CP-70429 (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

HY-171936

Ganglioside GM1 ammonium GM1 (d18:1/C18:0) ammonium; C18 Ganglioside GM1 (d18:1/18:0) ammonium	Endogenous Metabolite	Neurological Disease
Ganglioside GM1 (ammonium) is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. Ganglioside GM1 (ammonium) is one of the most abundant gangliosides in the brain which provides neuroprotection. Ganglioside GM1 (ammonium) exhibits anti-inflammatory property. Ganglioside GM1 (ammonium) has a well-balanced amphiphilic behavior. Ganglioside GM1 (ammonium) can reduce the fluidity of the plasma membrane that implies a retention and enrichment of the ganglioside in specific membrane domains that are called lipid rafts. Ganglioside GM1 (ammonium) can modify the process of differentiation, amplifies responses to neurotrophic factors, protects against excitatory amino acid-related neurotoxicity. Ganglioside GM1 (ammonium) can alleviate acute nerve cell damage through blocking cytotoxicity and potentiating neurotophic factors. Ganglioside GM1 (ammonium) can be studied in neurodegenerative diseases such as Alzheimer’s disease .

Cat. No.	Product Name	Type

HY-N12931F

Maackia amurensis Lectin (MAA/MAL II)-Biotinylated

Fluorescent Dyes

Maackia amurensis Lectin (MAA/MAL II)-Biotinylated is a plant lectin modified by biotin. Maackia amurensis Lectin (MAA/MAL II)-Biotinylated has the activity to recognize specific sugar structures, specifically the alpha-2, 3-linked sialic acid (HY-I0400). Maackia amurensis Lectin (MAA/MAL II)-Biotinylated has a very high affinity with avidin or streptavidin and this interaction can be used to fix it to solid surfaces or bind it to other molecules. Maackia amurensis Lectin (MAA/MAL II)-Biotinylated can be used to isolate and purify proteins or other molecules with specific sugar chain structures in affinity chromatography as well as for disease marker discovery and cancer research .

HY-D0871

CHES N-Cyclohexyltaurine	Fluorescent Dyes
CHES (N-Cyclohexyltaurine) is a biological buffer reagent that binds to influenza virus hemagglutinin (HA). CHES mimics the binding mode of sialic acid to the HA receptor-binding site .

HY-D1991

ATTO 647

Fluorescent Dyes

ATTO 647 is a carborhodamine fluorophore and imaging tracer with photostable properties. ATTO 647 serves as a fluorescent probe to investigate cell membrane structure and diffusion characteristics. When conjugated with wheat germ agglutinin, ATTO 647 specifically binds to N-acetyl-β-D-glucosamine and sialic acid residues on membrane glycoproteins, enabling single-molecule tracing of glycoprotein diffusion. ATTO 647 exhibits highly stable fluorescence properties with significantly reduced blinking in mounting media such as ROXS (AA/MV) and ROXS (TX/TQ), whereas its brightness properties vary in Ibidi-MM and Vectashield. ATTO 647 can also be used to label histone H2B-GFP in fixed cells for confocal microscopy photobleaching experiments .

Cat. No.	Product Name	Type

HY-NP0149

Sambucus Nigra Lectin (Biotinylated) SNA (Biotinylated)	Biochemical Assay Reagents
Sambucus Nigra Lectin (SNA) (Biotinylated) is a terminal sialic acid (SA) residue-binding lectin with biotinylation modification. Sambucus Nigra Lectin (Biotinylated) binds specifically to terminal sialic acid residues on captured IgG and its subclasses .

HY-NP0147

Wheat Germ Agglutinin (Fluorescein)

1 Publications Verification

WGA (Fluorescein)

Biochemical Assay Reagents

Wheat Germ Agglutinin (WGA) Fluorescein is a classic fluorescent label that specifically binds to sugar residues such as N-acetylglucosamine, N-acetylneuraminic acid and sialic acid. Wheat Germ Agglutinin Fluorescein performs regionally differential fluorescent staining of the ocular surface epithelial glycocalyx to assess its integrity, and causes no damage to the eye at safe concentrations. Wheat Germ Agglutinin Fluorescein is also used for staining structures including red blood cells, cultured cells, bacteria and pine wood nematodes, and facilitates the isolation of wheat-associated plant-growth-promoting rhizobacterial strains. Wheat Germ Agglutinin Fluorescein can be applied to the detection of ocular glycocalyx integrity and the research of related diseases such as pine wilt disease .

HY-D0871

CHES N-Cyclohexyltaurine	Biochemical Assay Reagents
CHES (N-Cyclohexyltaurine) is a biological buffer reagent that binds to influenza virus hemagglutinin (HA). CHES mimics the binding mode of sialic acid to the HA receptor-binding site .

HY-75102

4-Boronobenzoic acid	Biochemical Assay Reagents
4-Boronobenzoic acid is an organic compound. 4-Boronobenzoic acid forms reversible cyclic boronate esters with molecules containing cis-vicinal diol structures (such as sialic acid) through the boron atom, achieving molecular recognition and binding. 4-Boronobenzoic acid can be used in research of breast cancer .

HY-E70148

ST6 Gal Sialyltransferase 1 EC:2.4.3.1; ST6GAL1	Biochemical Assay Reagents
ST6 Gal Sialyltransferase 1 (EC:2.4.3.1, ST6GAL1) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates .

HY-E70150

ST6 Sialyltransferase 1 EC:2.4.3.3; Alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase 1	Biochemical Assay Reagents
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer .

HY-E70146

ST3 β-Gal α-2,3-Sialyltransferase 2 EC:2.4.3.4; ST3GAL2	Biochemical Assay Reagents
ST3 beta-Gal alpha-2,3-Sialyltransferase 2 (EC:2.4.3.4, ST3GAL2) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates .

HY-E70152

ST6 Sialyltransferase 4 EC:2.4.3.7; ST6GALNAC4; SIAT3-C	Biochemical Assay Reagents
ST6 Sialyltransferase 4 (EC:2.4.3.7; ST6GALNAC4; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. ST6 Sialyltransferase 4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation. .

HY-E70151

ST6 Sialyltransferase 2 ST6GALNAC2	Biochemical Assay Reagents
ST6 Sialyltransferase 2 (EC:2.4.3.3, ST6GALNAC2) add sialic acids to the nonreducing ends of glycoconjugates .

HY-E70149

ST6 Gal Sialyltransferase 2 EC:2.4.3.1; ST6GAL2	Biochemical Assay Reagents
ST6 Gal Sialyltransferase 2 (EC:2.4.3.1, ST6GAL2) catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. ST6 Gal Sialyltransferase 2 plays an important role in schizophrenic research .

HY-E70147

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase

Biochemical Assay Reagents

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

HY-W127461

Ganglioside GM2, Asialo

Gangliotriosylceramide

Biochemical Assay Reagents

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

Cat. No.	Product Name

HY-KE8012

Protein Deglycosylation Kit(for O-linked Glycans)

Protein Deglycosylation Kit (for O-linked Glycans)contains O-Glycosidase and a2-3,6,8,9 Neuraminidase.Both enzymes are crucial tool enzymes for glycosylation research and are used in combination to enzymatically release O-linked glycans from glycoproteins.O-Glycosidase is capable of cleaving and releasing Core 1 (Gal-B(1-3)-GalNAc-)and Core 3(GIcNAc-B(1-3)-GalNAc-)O-linked disaccharides,which are linked to the hydroxyl groups of Ser or Thr residues in glycoproteins.a2-3,6,8,9 Neuraminidase can remove a(2,3)-,a(2,6)-,a(2,8)-,and a(2,9)-sialic acid residues from the non-reducing termini of O-linked glycans.

Cat. No.	Product Name	Target	Research Area	Image

HY-P991636

AK006	Transmembrane Glycoprotein	Inflammation/Immunology
AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-P990163

Anti-Mouse Siglec-H Antibody (440c)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis .

HY-P992392

JM1-24-3	Transmembrane Glycoprotein Akt mTOR	Cancer
JM1-24-3 is an anti-MUC18 mouse monoclonal antibody with a K_d value of 1.60e-9 M. JM1-24-3 reduces the phosphorylation levels of p-AKT (Ser473) and p-mTOR (Ser2448) in a time-dependent manner. JM1-24-3 exhibits anticancer activity against melanoma. JM1-24-3 can be used in studies related to metastatic melanoma .

Species:	Human (23) Rat (1) Mouse (6) Cynomolgus (2)
Tag:	His (20) Tag Free (1) Avi (3) Myc (1) MBP (2) Flag (3) Fc (14)
Source:	HEK293 (28) CHO (1) Sf9 insect cells (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703444

	nanA Protein, S. haemolyticus sialic acid lyase; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; sialic acid aldolase; sialic acid lyase; nanA; Staphylococcus haemolyticus (strain JCSC1435); Lyase; 4.1.3.3	Others	E. coli
	nanA Protein, S. haemolyticus is the recombinant nanA protein, expressed by E. coli, with tag free tag.

HY-P79127

	Siglec-11 Protein, Human (E84A, K145Q, CHO, hFc) 1 Publications Verification sialic acid-binding Ig-like lectin 11; SIGLEC11; sialic acid-binding lectin 11; Siglec-11; sialic Acid Binding Ig-like Lectin 11	Human	CHO
	Siglec-11 Protein, Human (E84A, K145Q, CHO, hFc) is the recombinant human-derived Siglec-11 protein, expressed by CHO, with C-hFc labeled tag.

HY-P71314

	Siglec-E Protein, Mouse (HEK293, Fc) SiglecE; Siglec-E; sialic Acid Binding Ig-like Lectin E	Mouse	HEK293
	Siglec-E Protein is a mouse orthologue of human Siglec-9 and functions as a key immunosuppressive checkpoint molecule. Siglec-E interacts with CD36 to inhibits downstream VAV signaling involved in modified LDL uptake, thereby delaying atherosclerosis. The endogenous inducible Siglec-E plays crucial anti-inflammatory and neuroprotective roles following ischemic stroke. Siglec-E Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Siglec-E protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70960

	Siglec-5 Protein, Cynomolgus (HEK293, His) sialic acid-binding Ig-like lectin 5; Siglec-5	Cynomolgus	HEK293
	Siglec-5 Protein is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Siglec-5 is a member of the CD33-related subset of Siglecs and is expressed on myeloid cells of the hemopoietic system. Siglec-5 inhibits the response of innate immune cells, such as monocytes and neutrophils against pathogens. Siglec-5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Siglec-5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71309

	SIAE Protein, Human (HEK293, His) Sialate O-Acetylesterase; H-Lse; sialic Acid-Specific 9-O-Acetylesterase; SIAE; YSG2	Human	HEK293
	SIAE proteins play a key role in cellular processes by catalyzing the removal of the O-acetyl ester group specifically from the 9-position of the parent sialic acid N-acetylneuraminic acid. Through this enzymatic activity, SIAE helps regulate sialic acid modifications, affecting various biological functions associated with cell surface glycoconjugates. SIAE Protein, Human (HEK293, His) is the recombinant human-derived SIAE protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74548

	SIAE Protein, Human (sf9, His) Sialate O-Acetylesterase; H-Lse; sialic Acid-Specific 9-O-Acetylesterase; SIAE; YSG2	Human	Sf9 insect cells
	SIAE proteins play a key role in cellular processes by catalyzing the removal of the O-acetyl ester group specifically from the 9-position of the parent sialic acid N-acetylneuraminic acid. Through this enzymatic activity, SIAE helps regulate sialic acid modifications, affecting various biological functions associated with cell surface glycoconjugates. SIAE Protein, Human (sf9, His) is the recombinant human-derived SIAE protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P70959

	NANS Protein, Human (His) sialic Acid Synthase; N-Acetylneuraminate Synthase; N-Acetylneuraminate-9-Phosphate Synthase; N-Acetylneuraminic Acid Phosphate Synthase; N-Acetylneuraminic Acid Synthase; NANS; SAS	Human	E. coli
	NANS Protein is an enzyme that functions in the biosynthetic pathways of sialic acids. NANS protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. NANS Protein, Human (His) is the recombinant human-derived NANS protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72476

	Siglec-10 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 10; Siglec-10; SIGLEC10; SLG2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76642

	Siglec-10 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 10; Siglec-10; SIGLEC10; SLG2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704295

	Siglec-10 Protein, Human (HEK293, mFc) sialic acid-binding Ig-like lectin 10; Siglec-10; SIGLEC10; SLG2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (HEK293, mFc) is the recombinant human-derived Siglec-10 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P71311

	Siglec-7 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 7; AIRM-1; D-siglec; CD328; SIGLEC7	Human	HEK293
	Siglec-7 protein is a putative adhesion molecule that mediates sialic acid-dependent cell binding with preference for α-2,3- and α-2,6-linked sialic acids.It interacts with disialoganglioside and may be masked by cis interactions.Siglec-7 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-7 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70739

	Siglec-9 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; SIGLEC9	Human	HEK293
	Siglec-9 Protein is a member of the Siglec cell surface immunoglobulin family.Siglec-9 is highly expressed on human neutrophils and monocytes and low on natural killer cells, and sub-populations of T and B lymphocytes.Siglec-9 induces human neutrophil apoptosis and autophagy-like cell death and also inhibits tumor activity.Siglec-9 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-9 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72470

	Siglec-F Protein, Mouse (HEK293, His) SAF2; sialic acid binding Ig like lectin 8; SIGLEC-8; SIGLEC8L; SiglecF; Siglec-F	Mouse	HEK293
	Siglec-F Protein, a putative adhesion molecule, crucially mediates sialic-acid dependent binding to cells with a preferential affinity for alpha-2,3-linked sialic acid. Notably, its sialic acid recognition site may be concealed through cis interactions with sialic acids on the same cell surface. Siglec-F Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-F protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70448

	Siglec-10 Protein, Mouse (HEK293, Fc) SIGLEC10; SiglecG; Siglec-G; MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; Siglec-10; siglec-like gene 2; Siglec-like protein 2; SLG2sialic acid binding Ig-like lectin 10 Ig-like lectin 7	Mouse	HEK293
	Siglec-10 protein is an adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions. Siglec-10 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Siglec-10 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704878

	Siglec-10 Protein, Mouse (HEK293, His) SIGLEC10; SiglecG; Siglec-G; MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; Siglec-10; siglec-like gene 2; Siglec-like protein 2; SLG2sialic acid binding Ig-like lectin 10 Ig-like lectin 7	Mouse	HEK293

HY-P72021

	Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) sialic acid-binding Ig-like lectin 3 Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293
	Siglec-3/CD33 protein is a sialic acid-binding lectin that mediates cell-cell interactions and maintains immune cell quiescence. It prefers α-2,3- and α-2,6-linked glycans with sialic acid. Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) is the recombinant human-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-Myc, C-Fc labeled tag.

HY-P70742

	Siglec-15 Protein, Human (HEK293, Fc) 1 Publications Verification sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70738

	Siglec-15 Protein, Human (HEK293, mFc) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, mFc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P70743

	Siglec-15 Protein, Cynomolgus (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Cynomolgus	HEK293
	Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70744

	Siglec-15 Protein, Mouse (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Mouse	HEK293
	Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72475

	Siglec-15 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70767

	Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P72411

	Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; siglec-like gene 2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P72473

	Siglec-3/CD33 Protein, Mouse (HEK293, His) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Mouse	HEK293
	Siglec-3/CD33, a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. Siglec-3/CD33 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704284

	Siglec-3/CD33 Protein, Human (HEK293, mFc) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293
	Siglec-3/CD33 Protein, Human (HEK293, mFc) is the recombinant human-derived Siglec-3/CD33 protein, expressed by HEK293, with C-mFc tag.

HY-P72472

	Siglec-3/CD33 Protein, Human (HEK293, Fc-His) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293
	Siglec-3/CD33, a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. Siglec-3/CD33 Protein, Human (HEK293, Fc-His) is the recombinant human-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.

HY-P702008

	SLC35A1 Protein, Human (sf9, His, MBP, FLAG) SLC35A1; CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; Solute carrier family 35 member A1	Human	Sf9 insect cells
	SLC35A1 is a key player in intracellular transport, acting as a transporter to transport CMP-sialic acid from the cytoplasm to the Golgi apparatus. As an antiporter, it exchanges CMP-sialic acid for CMP, maintaining cellular homeostasis. SLC35A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

HY-P704879

	FITC-Labeled Siglec-3/CD33 Protein, Human (HEK293, His) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293

HY-P78910

	Siglec-15 Protein, Human (Biotinylated, HEK293, His-Avi) CD33 antigen-like 3; SIGLEC-15; CD33L3; sialic acid-binding Ig-like lectin 15; Siglec15; Siglec-15	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P72471

	Siglec-5 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170	Human	HEK293
	Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71023

	Siglec-5 Protein, Human (HEK293, His-Flag-Fc) sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170	Human	HEK293
	Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, His-Flag-Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc, C-Flag, C-6*His labeled tag.

HY-P702522

	MAG/Siglec-4a Protein, Rat (HEK293, His) GMAsialic acid binding Ig-like lectin 4A; MAG; myelin associated glycoprotein; myelin-associated glycoprotein; sialic acid-binding immunoglobulin-like lectin 4A; Siglec4a; Siglec-4a; S-MAG	Rat	HEK293
	MAG/Siglec-4a protein binds gangliosides, RTN4R, and RTN4RL2, mediating myelinating cell-neuron interactions. It maintains axon myelination, protects motoneurons, prevents axon degeneration, and inhibits neurite outgrowth. It exists as a monomer or homodimer, interacting with BSG isoform 2. MAG/Siglec-4a Protein, Rat (HEK293, His) is the recombinant rat-derived MAG/Siglec-4a protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P703316

	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT; SLC17A5; Homo sapiens; Human; AST	Human	HEK293
	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC17A5, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

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Host:	Mouse (4) Rabbit (7)
Reactivity:	Human (11) Rat (1) Mouse (2)
Application:	IHC-P (6) IF-Tissue (1) IP (1) WB (4) FC (5) ELISA (4)
Isotype:	IgG (7)
Conjugation:	Non-conjugated (11) Biotin (3)
Clonality:	Monoclonal (9) Recombinant (5)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810427

	MAG Antibody (YA9740) GMA, MAG, MAG_HUMAN, Myelin associated glycoprotein, Myelin-associated glycoprotein, S MAG, S-MAG, sialic acid binding Ig like lectin 4A, sialic acid binding immunoglobulin like lectin 4A, Siglec 4a	WB, IHC-P, IF-Tissue, IP	Human, Mouse, Rat
	MAG Antibody (YA9740) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to MAG.

HY-P81548

	CD169 Antibody (YA1293) CD169 antibody; CD169 antigen antibody; dJ1009E24.1 antibody; DKFZp667F058 antibody; FLJ00051 antibody; FLJ00055 antibody; FLJ00073 antibody; FLJ00411 antibody; FLJ32150 antibody; sialic acid binding Ig like lectin 1 antibody; sialic acid binding Ig-like lectin 1, sialoadhesin antibody; sialic acid binding immunoglobulin like lectin 1 antibody; sialic acid-binding Ig-like lectin 1 antibody; Sialoadhesin antibody; Siglec 1 antibody; SN antibody; SN_HUMAN antibody	WB, FC	Human, Mouse
	CD169 Antibody (YA1293) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD169.

HY-P81515

	CD169 Antibody (YA1260) SIGLEC1; SN; Sialoadhesin; sialic acid-binding Ig-like lectin 1 (Siglec-1); CD169	IHC-P	Human
	CD169 Antibody (YA1260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD169.

HY-P81515A

	CD169 Antibody (YA1260)(PBS only) SIGLEC1; SN; Sialoadhesin; sialic acid-binding Ig-like lectin 1 (Siglec-1); CD169	IHC-P	Human
	CD169 Antibody (YA1260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD169.

HY-P85088

	CD33 Antibody (YA4780) CD33; SIGLEC3; Myeloid cell surface antigen CD33; sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33	WB, ELISA	Human
	CD33 Antibody (YA4780) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD33.

HY-P84989

	CD33 Antibody (YA4681) CD33; SIGLEC3; Myeloid cell surface antigen CD33; sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33; CD33 nanobody;	ELISA, FC	Human
	CD33 Antibody (YA4681) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD33.

HY-P85023

	CD33 Antibody (YA4715) CD33; SIGLEC3; Myeloid cell surface antigen CD33; sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD antigen CD33; CD33 nanobody;	FC, ELISA	Human
	CD33 Antibody (YA4715) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD33.

HY-P81522

	CD22 Antibody (YA1267) CD22; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22	IHC-P	Human
	CD22 Antibody (YA1267) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD22.

HY-P84975

	CD22 Antibody (YA4667) CD22; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22	FC, ELISA	Human
	CD22 Antibody (YA4667) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD22.

HY-P81522A

	CD22 Antibody (YA1267)(PBS only) CD22; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22	IHC-P	Human
	CD22 Antibody (YA1267) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD22.

HY-P810387

	Fetuin A Antibody (YA9704) 59 kDa bone sialic acid containing protein, A2HS, Aa2 066, AHS, Ahsg, Alpha 2 HS glycoprotein, Alpha 2 HS glycoprotein chain A, Alpha 2 HS glycoprotein chain B, Alpha 2 Z globulin, Alpha 2HS glycoprotein	WB, IHC-P, FC	Human
	Fetuin A Antibody (YA9704) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Fetuin A.

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Cat. No.	Product Name		Classification

HY-148476

Tri-GalNAc-DBCO		DBCO
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation .

Cat. No.	Product Name		Classification

HY-147266

Elebsiran sodium VIR-2218 sodium		siRNAs siRNA drugs
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .

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