2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. AK006

AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research.

For research use only. We do not sell to patients.

AK006

AK006 Chemical Structure

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Based on 1 publication(s) in Google Scholar

AK006 Related Antibodies

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Description

AK006 is a humanized IgG1 monoclonal antibody agonist targeting Sialic acid-binding immunoglobulin-like lectin6 (Siglec-6). AK006 potently inhibits IgE-mediated human mast cell activation. AK006 can be used for inflammatory diseases like chronic urticaria (CU) and asthma research[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

Siglec-6
In Vitro

AK006 can extensively inhibit both IgE-dependent and non-IgE-dependent activation and degranulation of mast cells, covering various signaling pathways including FcεRI, complement component C5a receptor, and MRGPRX2[1][2].
AK006, compared with another inhibitory antibody Lirentelimab (HY-P99371) (targeting Siglec-8), demonstrates a stronger ability to inhibit mast cell degranulation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AK006 Related Antibodies
In Vivo

AK006 can inhibit systemic allergic reactions mediated by IgE in a humanized mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Gene ID

946  [NCBI]

Accession

O43699
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

143.91 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

N/A
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AK006 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AK006AK 006AK-006Transmembrane GlycoproteinSialic acid-binding immunoglobulin-like lectin6Siglec-6Monoclonal antibodyIgEhuman mast cellChronic urticarialCUAsthmaInhibitorinhibitorinhibit

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AK006
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HY-P991636
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