SIGLEC6 - sialic acid binding Ig like lectin 6 Gene

Also Known as CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 946

About SIGLEC6

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,517,819-51,531,670 (from NCBI)

This gene has 9 transcripts (splice variants), 66 orthologues and 16 paralogues. Biased expression in placenta (RPKM 50.1) and lung (RPKM 2.3).

Summary

This gene encodes a member of the Siglec (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and Leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

SIGLEC6 Products (6)

mRNA Protein Name
NM_001177547.3 NP_001171018.1 sialic acid-binding Ig-like lectin 6 isoform 4
NM_001177548.3 NP_001171019.1 sialic acid-binding Ig-like lectin 6 isoform 5 precursor
NM_001177549.3 NP_001171020.1 sialic acid-binding Ig-like lectin 6 isoform 6 precursor
NM_001245.7 NP_001236.4 sialic acid-binding Ig-like lectin 6 isoform 1 precursor
NM_198845.6 NP_942142.3 sialic acid-binding Ig-like lectin 6 isoform 2 precursor
NM_198846.6 NP_942143.3 sialic acid-binding Ig-like lectin 6 isoform 3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25187624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC6 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (32 - 131)

ig

ig: Immunoglobulin domain (163 - 217)

I-set

I-set: Immunoglobulin I-set domain (254 - 336)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 6

  • CD33 antigen-like 1

SIGLEC6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIGLEC6 O43699 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
SIGLEC6 O43699 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
SIGLEC6 O43699 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGLEC6 Proteins

Cat. No. Product Name Accession Purity
HY-P71031 Siglec-6 Protein, Human (HEK293, Fc) O43699-3 (Q27-V331) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700825 Siglec-6 Protein, Human (HEK293, His-Avi) O43699-3 (Q27-V331) ≥ 95%, as determined by reducing Bis-Tris PAGE.

SIGLEC6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83847 CD327 Antibody (YA3544) IHC-P, FC, ELISA Human
HY-P83847A CD327 Antibody (YA3544)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Non-Gestational Choriocarcinoma

  • Choriocarcinoma, Non-Gestational
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991636 AK006 98.78% Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12904 SIGLEC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIGLEC6 MGD MGI:99440
Rattus norvegicus SIGLEC6 RGD RGD:1305432
Macaca mulatta SIGLEC6 VGNC VGNC:77216
Others SIGLEC6 NCBI