SIGLEC6 - sialic acid binding Ig like lectin 6 Gene

Homo sapiens

Also known as CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327

Gene ID: 946 | Gene type: protein coding

About SIGLEC6

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,517,819-51,531,670 (from NCBI)

This gene has 9 transcripts (splice variants), 66 orthologues and 16 paralogues. Biased expression in placenta (RPKM 50.1) and lung (RPKM 2.3).

Summary

This gene encodes a member of the Siglec (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and Leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

SIGLEC6 Products(6)

mRNA	Protein	Name
NM_001177547.3	NP_001171018.1	sialic acid-binding Ig-like lectin 6 isoform 4
NM_001177548.3	NP_001171019.1	sialic acid-binding Ig-like lectin 6 isoform 5 precursor
NM_001177549.3	NP_001171020.1	sialic acid-binding Ig-like lectin 6 isoform 6 precursor
NM_001245.7	NP_001236.4	sialic acid-binding Ig-like lectin 6 isoform 1 precursor
NM_198845.6	NP_942142.3	sialic acid-binding Ig-like lectin 6 isoform 2 precursor
NM_198846.6	NP_942143.3	sialic acid-binding Ig-like lectin 6 isoform 3 precursor

SIGLEC6 Protein Structure

V-set

I-set

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

sialic acid-binding Ig-like lectin 6

CD33 antigen-like 1

Recombinant SIGLEC6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71031	Siglec-6 Protein, Human (HEK293, Fc)	O43699-3 (E27-V331)	≥95%
HY-P700825	Siglec-6 Protein, Human (HEK293, His-Avi)	O43699-3 (Q27-V331)	≥95%

Related Diseases

Diseases

Alias

Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12904	SIGLEC6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIGLEC6	MGD	MGI:99440
Rattus norvegicus	SIGLEC6	RGD	RGD:1305432
Macaca mulatta	SIGLEC6	VGNC	VGNC:77216
Others	SIGLEC6	NCBI

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