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CD327 Antibody (YA3544)

(Synonyms: SIGLEC6; CD33L; OBBP1; CD33L1; CD33L2; CDW327)

CD327 Antibody (YA3544) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD327.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    IHC-P, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS with 0.05% sodium azide

  • Conjugation:
    Non-conjugated
  • CD327 Antibody (YA3544) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

CD327 Antibody (YA3544) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD327.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 60 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 50 kDa
Immunogen

Purified recombinant fragment of human CD327 (AA: extra 27-347) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS with 0.05% sodium azide

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD327 can bind to TNFRSF3/LTBR. CD327 can modulate the effects of the decoy receptor TNFRSF6B. CD327 can act as a ligand for TNFRSF14/HVEM. After binding to TNFRSF14/HVEM, CD327 can transmit co-stimulatory signals to T cells, thereby promoting T cell proliferation and IFNG production[1].

  • Subcellular Localization

    Cell membrane; Single-pass type II membrane protein; Secreted; Cytoplasm

  • Expression


    Tissue_specificity:It is primarily expressed in the spleen, but also found in brain tissue. Expression is weaker in peripheral lymphoid tissues, as well as in the heart, placenta, liver, lungs, appendix, and kidneys. It has not been observed in fetal tissues, endocrine glands, or non-hematopoietic tumor cell lines.

    Induction:Up-regulated after T-cell activation

  • Isoforms & Post-Translational Modification

    CD327 has 2 isomers: O43557-1: 26350 Da (predicted); O43557-2: 22395 Da (predicted).
    N-glycosylated;The soluble form of isoform 1 derives from the membrane form by proteolytic processing

  • Subunit

    Homotrimer. Interacts with TNFRSF14

  • SwissProt ID

    O43699 

  • Gene ID
    946 [NCBI]
  • Synonyms

    SIGLEC6; CD33L; OBBP1; CD33L1; CD33L2; CDW327

[1]. Tamada K, et al. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol. 2000 Apr 15;164(8):4105-10. [Content Brief]

CD327 Antibody (YA3544) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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