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silicon-rhodamine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Caspase (1) Drug Derivative (1) Fluorescent Dye (7) Ser/Thr Protease (1)
By Research Areas:	Cancer (1)
Click Chemistry:	DBCO (1)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D2222

5-HMSiR-Hoechst	Fluorescent Dye	Others
5-HMSiR-Hoechst is a DNA probe. 5-HMSiR-Hoechst comprises Hoechst 33258 and spontaneously blinking far-red hydroxymethyl silicon-rhodamine (HMSiR). 5-HMSiR-Hoechst can stain living cells. Ex/Em=640 nm/675 nm .

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-D2940

SiR-SNAP SiR650-BG	Fluorescent Dye	Others
SiR-SNAP (SiR650-BG) is a SiR-labeled SNAP tag near-infrared fluorescent probe (Ex/Em: 645 nm/661 nm). SiR-SNAP combines excellent optical properties, good cell membrane permeability, and environmentally sensitive fluorescence characteristics, providing a powerful tool for the dynamic study of proteins in living cells .

HY-D3264

SiR-PEG4-DBCO	Fluorescent Dye	Others
SiR-PEG4-DBCO is a novel fluorescent labeling molecule that combines the superior fluorescent properties of silicon-rhodamine dyes with the functionalities of polyethylene glycol (PEG) and Click Chemistry. SiR dyes exhibit excellent photostability under identical excitation conditions, making them suitable for long-term cellular imaging (Ex = 640 nm, Em = 670-680 nm).

HY-D3284

CSF1	Fluorescent Dye	Others
CSF1 is a silicon-rhodamine-based, fluorescence-activatable probe with selectivity for Cu ⁺. CSF1 colocalizes with the endoplasmic reticulum in live cells .

HY-P11476

(Z-AR)2Rh110	Ser/Thr Protease Fluorescent Dye Drug Derivative	Others
(Z-AR)2Rh110 is a Rhodamine derivative. (Z-AR)2Rh110 can be hydrolyzed by trypsin .

Cat. No.	Product Name	Type

HY-D2222

5-HMSiR-Hoechst	Fluorescent Dyes
5-HMSiR-Hoechst is a DNA probe. 5-HMSiR-Hoechst comprises Hoechst 33258 and spontaneously blinking far-red hydroxymethyl silicon-rhodamine (HMSiR). 5-HMSiR-Hoechst can stain living cells. Ex/Em=640 nm/675 nm .

HY-D2940

SiR-SNAP SiR650-BG	Fluorescent Dyes
SiR-SNAP (SiR650-BG) is a SiR-labeled SNAP tag near-infrared fluorescent probe (Ex/Em: 645 nm/661 nm). SiR-SNAP combines excellent optical properties, good cell membrane permeability, and environmentally sensitive fluorescence characteristics, providing a powerful tool for the dynamic study of proteins in living cells .

HY-D3264

SiR-PEG4-DBCO	Fluorescent Dyes
SiR-PEG4-DBCO is a novel fluorescent labeling molecule that combines the superior fluorescent properties of silicon-rhodamine dyes with the functionalities of polyethylene glycol (PEG) and Click Chemistry. SiR dyes exhibit excellent photostability under identical excitation conditions, making them suitable for long-term cellular imaging (Ex = 640 nm, Em = 670-680 nm).

HY-D3284

CSF1	Fluorescent Dyes
CSF1 is a silicon-rhodamine-based, fluorescence-activatable probe with selectivity for Cu ⁺. CSF1 colocalizes with the endoplasmic reticulum in live cells .

Cat. No.	Product Name	Target	Research Area

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-P11476

(Z-AR)2Rh110	Ser/Thr Protease Fluorescent Dye Drug Derivative	Others
(Z-AR)2Rh110 is a Rhodamine derivative. (Z-AR)2Rh110 can be hydrolyzed by trypsin .

Cat. No.	Product Name		Classification

HY-D3264

SiR-PEG4-DBCO		DBCO
SiR-PEG4-DBCO is a novel fluorescent labeling molecule that combines the superior fluorescent properties of silicon-rhodamine dyes with the functionalities of polyethylene glycol (PEG) and Click Chemistry. SiR dyes exhibit excellent photostability under identical excitation conditions, making them suitable for long-term cellular imaging (Ex = 640 nm, Em = 670-680 nm).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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