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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
thioester
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "thioester" in MCE Product Catalog:
25
25 Publications Verification
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Cardiovascular Disease Neurological Disease Endocrinology Cancer
IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
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2 Cited Publications
Synonyms: Palmitoyl CoA lithium
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Esterase, pig liver (CESs), namely carboxylate hydrolases, are widely distributed in nature, commonly found in mammalian liver, and often used in biochemical research. Esterase catalyzes the hydrolysis of a variety of endogenous and exogenous substrates, including esters, thioesters, carbamates, and amides, hydrolyzing carboxylic acid esters to the corresponding alcohols and carboxylic acids .
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CpG ODN 10101 (ODN 10101; CPG 10101) is a selective agonist targeting TLR9, a synthetic oligodeoxynucleotide modified with phosphate thioester. CpG ODN 10101 activates B cells and plasmacytoid dendritic cells (pDCs), inducing the production of cytokines and chemokines such as interferon-IFN-α, interferon-inducible protein IP-10, and 2'5'-oligoadenylate synthase (2'5'-OAS), regulating innate immunity and promoting Th1 adaptive immune responses. CpG ODN 10101 also possesses antiviral properties and enhances vaccine immunogenicity, making it suitable as an immunomodulator and vaccine adjuvant for vaccine development in chronic hepatitis C and infectious diseases such as melioidosis, pertussis, and respiratory syncytial virus (RSV) .
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Human Gut Microbiota Metabolites Natural Products Other Diseases Endogenous metabolite Disease Research Fields
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Cat. No.: HY-175606
CAS No.: 2588489-03-4
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EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increase tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC) .
Synonyms: N-Acetyl-L-serine
Cat. No.: HY-P10486
CAS No.: 200010-31-7
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L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice .
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UC-764864 is a selective UBE2N inhibitor. UC-764864 covalently binds UBE2N catalytic Cys87, blocks ubiquitin-UBE2N thioester formation and polyubiquitin chain synthesis. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates, and induces cell apoptosis. UC-764864 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-P4909
CAS No.: 200010-29-3
Synonyms: AIP-I
Synonyms: Oleoyl-CoA lithium
Cat. No.: HY-103436
CAS No.: 13116-77-3
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NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation .
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Acetyl-CoA synthetase (ACS) is a key enzyme that catalyzes the conversion of acetic acid to acetyl-CoA (Ac-CoA). Acetyl-CoA synthetase catalyzes the formation of a thioester bond between coenzyme A and carboxylic acid, while hydrolyzing ATP to AMP and pyrophosphate. Acetyl-CoA synthetase has two mammalian isoforms, mediates the only pathway for the conversion of free acetic acid to acetyl-CoA in mammals, serves as a marker gene for the Wood-Ljungdahl pathway, and catalyzes the exchange between carbonyl groups and CoA-acetyl-CoA. Acetyl-CoA synthetase can be used for studies of metabolism-related diseases .
Cat. No.: HY-E70394
CAS No.: 75179-85-0
Synonyms: Acetonyl-coenzyme A
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S-Acetonyl-CoA (Acetonyl-coenzyme A) is a non-reactive structural analog of acetyl-CoA that acts as a competitive inhibitor against multiple target enzymes. S-Acetonyl-CoA lacks the characteristic thioester group of acetyl-CoA, retaining only a thioether structure. S-Acetonyl-CoA competes with acetyl-CoA for binding to citrate synthase, phosphate transacetylase, carnitine acetyltransferase, and N-myristoyltransferase 1. S-Acetonyl-CoA serves as a reagent for investigating acetyl-CoA-dependent physiological processes .
Cat. No.: HY-CE00775
CAS No.: 10478-66-7
Synonyms: o-Hydroxybenzoyl-coenzyme A
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2-Hydroxybenzoyl-CoA (o-Hydroxybenzoyl-coenzyme A) is a coenzyme A thioester of o-hydroxybenzoic acid and substrate for esterolysis. 2-Hydroxybenzoyl-CoA serves as a substrate for studies of acyl-CoA formation, acyl transfer, and peptide bond formation reactions and enzymes .
Cat. No.: HY-P5300A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
