9012-31-1
Chemical Structure
Acetyl-CoA synthetase
Synonym(s): ACS
- CAS No.: 9012-31-1
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Acetyl-CoA synthetase]
Biological Activity: Acetyl-CoA synthetase (ACS) is a key enzyme that catalyzes the conversion of acetic acid to acetyl-CoA (Ac-CoA). Acetyl-CoA synthetase catalyzes the formation of a thioester bond between coenzyme A and carboxylic acid, while hydrolyzing ATP to AMP and pyrophosphate. Acetyl-CoA synthetase has two mammalian isoforms, mediates the only pathway for the conversion of free acetic acid to acetyl-CoA in mammals, serves as a marker gene for the Wood-Ljungdahl pathway, and catalyzes the exchange between carbonyl groups and CoA-acetyl-CoA. Acetyl-CoA synthetase can be used for studies of metabolism-related diseases[1][2].
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Acetyl-CoA synthetase | Acetyl-CoA synthetase (ACS) is a key enzyme that catalyzes the conversion of acetic acid to acetyl-CoA (Ac-CoA). Acetyl-CoA synthetase catalyzes the formation of a thioester bond between coenzyme A and carboxylic acid, while hydrolyzing ATP to AMP and pyrophosphate. Acetyl-CoA synthetase has two mammalian isoforms, mediates the only pathway for the conversion of free acetic acid to acetyl-CoA in mammals, serves as a marker gene for the Wood-Ljungdahl pathway, and catalyzes the exchange between carbonyl groups and CoA-acetyl-CoA. Acetyl-CoA synthetase can be used for studies of metabolism-related diseases. | |||||||||||||||||||||
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References
- [1]. Hallows WC, et al. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 05;103(27):10230-10235. [Content Brief]
- [2]. Can M, et al. Structure, Function, and Mechanism of the Nickel Metalloenzymes, CO Dehydrogenase, and Acetyl-CoA Synthase. Chemical Reviews, 2014, 114(8): 4149-4174.
