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Cat. No.: HY-CE00775

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2-Hydroxybenzoyl-CoA

(Synonyms: o-Hydroxybenzoyl-coenzyme A)

2-Hydroxybenzoyl-CoA (o-Hydroxybenzoyl-coenzyme A) is a coenzyme A thioester of o-hydroxybenzoic acid and substrate for esterolysis. 2-Hydroxybenzoyl-CoA serves as a substrate for studies of acyl-CoA formation, acyl transfer, and peptide bond formation reactions and enzymes.

For research use only. We do not sell to patients.

CAS No.: 10478-66-7
Formula: C₂₈H₄₀N₇O₁₈P₃S
Molecular Weight:887.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

2-Hydroxybenzoyl-CoA Chemical Structure

CAS No.: 10478-66-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

2-Hydroxybenzoyl-CoA undergoes esterolysis via phenolate-assisted water attack on the benzoyl moiety’s carbonyl carbon, with hydrolysis rate nearly constant over pH 9.6-12.1^[1].
2-Hydroxybenzoyl-CoA exists predominantly in an intramolecular adenyl-benzoyl complex under physiological conditions, which may contribute to acyl-CoA substrate specificity of acyl-CoA: amino acid N-acyltransferases^[1].
2-Hydroxybenzoyl-CoA has a characteristic ultraviolet absorption spectrum with a phenolate absorbance band that red shifts with increasing pH, exploitable for discontinuous enzymatic assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10478-66-7
Molecular Weight 887.64
Formula C₂₈H₄₀N₇O₁₈P₃S
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)([C@@H](O)C(NCCC(NCCSC(C4=CC=CC=C4O)=O)=O)=O)C)(O)=O)(O)=O)O3
Synonyms

o-Hydroxybenzoyl-coenzyme A
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leslie T. Webster, et al. Coenzyme a thioesters of benzoic, hydroxybenzoic, phenylacetic, and bile acids. Methods in Enzymology. Academic Press. Volume 77, 1981. Pages 430-436.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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