2-Hydroxybenzoyl-CoA lithium  (Synonyms: o-Hydroxybenzoyl-coenzyme A lithium)

2-Hydroxybenzoyl-CoA (o-Hydroxybenzoyl-coenzyme A) lithium is a coenzyme A thioester of o-hydroxybenzoic acid and substrate for esterolysis. 2-Hydroxybenzoyl-CoA lithium serves as a substrate for studies of acyl-CoA formation, acyl transfer, and peptide bond formation reactions and enzymes^[1].

2-Hydroxybenzoyl-CoA lithium undergoes esterolysis via phenolate-assisted water attack on the benzoyl moiety’s carbonyl carbon, with hydrolysis rate nearly constant over pH 9.6-12.1^[1].
2-Hydroxybenzoyl-CoA lithium exists predominantly in an intramolecular adenyl-benzoyl complex under physiological conditions, which may contribute to acyl-CoA substrate specificity of acyl-CoA: amino acid N-acyltransferases^[1].
2-Hydroxybenzoyl-CoA lithium has a characteristic ultraviolet absorption spectrum with a phenolate absorbance band that red shifts with increasing pH, exploitable for discontinuous enzymatic assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

887.64 (free acid)

C₂₈H₄₀N₇O₁₈P₃S·xLi

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)([C@@H](O)C(NCCC(NCCSC(C4=CC=CC=C4O)=O)=O)=O)C)(O)=O)(O)=O)O3.[Li].[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Leslie T. Webster, et al. Coenzyme a thioesters of benzoic, hydroxybenzoic, phenylacetic, and bile acids. Methods in Enzymology. Academic Press. Volume 77, 1981. Pages 430-436.