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tryptanthrin derivative

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-146316
    Topoisomerase II inhibitor 6

    		Topoisomerase Cancer
    Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .
    Topoisomerase II inhibitor 6
  • HY-184078
    8-F-2-(Me-Pip-Me)-Tryptanthrin

    		Drug Derivative Indoleamine 2,3-Dioxygenase (IDO) Tau Protein iGluR Neurological Disease
    8-F-2-(Me-Pip-Me)-Tryptanthrin is a tryptanthrin derivative with blood-brain barrier penetration. 8-F-2-(Me-Pip-Me)-Tryptanthrin protects neurons from Aβ-induced apoptosis, inhibits Aβ-induced Tau protein hyperphosphorylation and neuronal synaptic damage, and improves learning and memory abilities in Alzheimer's disease mice. 8-F-2-(Me-Pip-Me)-Tryptanthrin can be used for the research of nervous system diseases, including diseases related to abnormal Tau protein phosphorylation and abnormal PSD-95 function .
    8-F-2-(Me-Pip-Me)-Tryptanthrin
  • HY-180812
    Antibacterial agent 312

    		Bacterial Infection
    Antibacterial agent 312 (Compound 8c) is a highly effective antibacterial agent that can effectively damage the integrity of bacterial membranes and enhance membrane permeability. Antibacterial agent 312 exhibits MIC values against Vibrio parahaemolyticus and Vibrio alginolyticus of 6 and 16 μg/mL respectively. Antibacterial agent 312 has bactericidal activity against Vibrio parahaemolyticus and can effectively inhibit the formation of biofilms. Antibacterial agent 312 demonstrates excellent biological safety and can be used for research on the infection of the aquatic pathogen Vibrio parahaemolyticus .
    Antibacterial agent 312
  • HY-182310
    Antibacterial agent 333

    		Bacterial Infection
    Antibacterial agent 333, Tryptanthrin (HY-N6607) derivative, is a antibacterial agent with antibacterial activity against Vibrio parahaemolyticus (MIC50 = 8 μg/mL) and Vibrio alginolyticus (MIC50 = 16 μg/mL). Antibacterial agent 333 inhibits biofilm formation and maturation. Antibacterial agent 333 exhibits activity against drug-resistant Vibrio strains. Antibacterial agent 333 lacks cytotoxicity toward mammalian cells and has no hemolytic activity. Antibacterial agent 333 can be used for the research of infection .
    Antibacterial agent 333

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