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Cat. No.: HY-184078

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8-F-2-(Me-Pip-Me)-Tryptanthrin

8-F-2-(Me-Pip-Me)-Tryptanthrin is a tryptanthrin derivative with blood-brain barrier penetration. 8-F-2-(Me-Pip-Me)-Tryptanthrin protects neurons from Aβ-induced apoptosis, inhibits Aβ-induced Tau protein hyperphosphorylation and neuronal synaptic damage, and improves learning and memory abilities in Alzheimer's disease mice. 8-F-2-(Me-Pip-Me)-Tryptanthrin can be used for the research of nervous system diseases, including diseases related to abnormal Tau protein phosphorylation and abnormal PSD-95 function.

For research use only. We do not sell to patients.

CAS No.: 1563106-65-9
Formula: C₂₁H₁₉FN₄O₂
Molecular Weight:378.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

8-F-2-(Me-Pip-Me)-Tryptanthrin Chemical Structure

CAS No.: 1563106-65-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Biological Activity

Description

IC₅₀ & Target^[1]

IDO1

IDO2

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

All iGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.09 μM Compound: 5a	Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 hrs Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 hrs	[PMID: 31580660]

Chemical Information

CAS No. 1563106-65-9
Molecular Weight 378.40
Formula C₂₁H₁₉FN₄O₂
SMILES

O=C1C2=CC(F)=CC=C2N3C(C4=C(N=C13)C=CC(CN5CCN(CC5)C)=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kuang, et al. Use of tryptanthrin derivatives for the treatment of neurological disorders. CN111135178A. China. 2018-11-02.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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8-F-2-(Me-Pip-Me)-Tryptanthrin

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

All iGluR Isoforms