1563106-65-9
Chemical Structure
8-F-2-(Me-Pip-Me)-Tryptanthrin
- CAS No.: 1563106-65-9
- Formula:C21H19FN4O2
- Molecular Weight:378.40
InChIKey: GJCZYPVNSMSOLT-UHFFFAOYSA-N
SMILES: O=C1C2=CC(F)=CC=C2N3C(C4=C(N=C13)C=CC(CN5CCN(CC5)C)=C4)=O
Biological Activity: 8-F-2-(Me-Pip-Me)-Tryptanthrin is a tryptanthrin derivative with blood-brain barrier penetration. 8-F-2-(Me-Pip-Me)-Tryptanthrin protects neurons from Aβ-induced apoptosis, inhibits Aβ-induced Tau protein hyperphosphorylation and neuronal synaptic damage, and improves learning and memory abilities in Alzheimer's disease mice. 8-F-2-(Me-Pip-Me)-Tryptanthrin can be used for the research of nervous system diseases, including diseases related to abnormal Tau protein phosphorylation and abnormal PSD-95 function[1].
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8-F-2-(Me-Pip-Me)-Tryptanthrin | 8-F-2-(Me-Pip-Me)-Tryptanthrin is a tryptanthrin derivative with blood-brain barrier penetration. 8-F-2-(Me-Pip-Me)-Tryptanthrin protects neurons from Aβ-induced apoptosis, inhibits Aβ-induced Tau protein hyperphosphorylation and neuronal synaptic damage, and improves learning and memory abilities in Alzheimer's disease mice. 8-F-2-(Me-Pip-Me)-Tryptanthrin can be used for the research of nervous system diseases, including diseases related to abnormal Tau protein phosphorylation and abnormal PSD-95 function. | |||||||||||||||||||||
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Keywords
