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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
type 2 diabetic nephropathy
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "type 2 diabetic nephropathy" in MCE Product Catalog:
1
Cat. No.: HY-14923
CAS No.: 473289-62-2
Synonyms: AVE 7688
Research Areas:
Ilepatril, a dual inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase, has inhibitory effects in the type 2 diabetic nephropathy model in obese Zucker diabetic fatty (ZDF) rats. Ilepatril significantly reduced albuminuria in a dose-dependent manner and may be a strategy distinct from metabolic control to inhibit type 2 diabetic nephropathy .
Cat. No.: HY-100819
CAS No.: 1365266-79-0
Target:
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RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy .
Cat. No.: HY-P11736
CAS No.: 1489241-80-6
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Research Areas:
Cat. No.: HY-P12142
Target:
Research Areas:
GLP-1 receptor agonist D13 is a long-acting GLP-1R agonist peptide conjugated with a C20 fatty acid chain. It activates GLP-1R-mediated cAMP signaling in HEK293 cells, with an EC50 of 0.036 nM. GLP-1 receptor agonist D13 can be used in studies related to type 2 diabetes, diabetic nephropathy and obesity .
Cat. No.: HY-124487
CAS No.: 1062624-71-8
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GK-136901 is an orally active, dual Nox1/Nox4 NADPH oxidase inhibitor with a Ki of 160 nM for Nox1 and 165 nM for Nox4. GK-136901 potently blocks high glucose-induced intracellular reactive oxygen species production, p38-MAPK phosphorylation, and upregulation of TGF-β1/2 and fibronectin (fibronectin) in renal cells. GK-136901 also inhibits the proliferation of mouse pulmonary vascular cells under hypoxic conditions. GK-136901 is applicable to the research on the pathogenesis of type 2 diabetic nephropathy, high glucose-related renal lesions and pulmonary hypertension .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
