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Sibiriquinone A

Sibiriquinone A is a diterpene which can be extracted from Veronicastrum sibiricum. Sibiriquinone A exerts immunosuppressive activity and can be used for relevant researches.

For research use only. We do not sell to patients.

CAS No.: 723300-08-1
Formula: C₁₉H₂₀O₂
Molecular Weight:280.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Sibiriquinone A Chemical Structure

CAS No.: 723300-08-1

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Sample (0.1mg)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Sibiriquinone A is a diterpene which can be extracted from Veronicastrum sibiricum. Sibiriquinone A exerts immunosuppressive activity and can be used for relevant researches^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	0.34 μM Compound: 1, sibiriquinone a	Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay Inhibition of HIF1 activation in human AGS cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay	[PMID: 17583950]
AGS	IC₅₀	21.2 μM Compound: 1, sibiriquinone a	Viability of human AGS cells under hypoxic conditions after 24 hrs by MTT assay Viability of human AGS cells under hypoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]
AGS	IC₅₀	35.7 μM Compound: 1, sibiriquinone a	Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay Viability of human AGS cells under normoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]
Hep 3B2	IC₅₀	>50 μM Compound: 1, sibiriquinone a	Viability of human Hep3B cells under hypoxic conditions after 24 hrs by MTT assay Viability of human Hep3B cells under hypoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]
Hep 3B2	IC₅₀	>50 μM Compound: 1, sibiriquinone a	Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay Viability of human Hep3B cells under normoxic conditions after 24 hrs by MTT assay	[PMID: 17583950]
Hep 3B2	IC₅₀	0.28 μM Compound: 1, sibiriquinone a	Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay Inhibition of HIF1 activation in human Hep3B cells assessed as inhibition of hypoxia-induced luciferase expression after 16 hrs by reporter assay	[PMID: 17583950]
Hep 3B2	IC₅₀	0.4 μM Compound: 1, sibiriquinone a	Inhibition of hypoxia-induced HIF1alpha accumulation in Hep3B cells Inhibition of hypoxia-induced HIF1alpha accumulation in Hep3B cells	[PMID: 17583950]
Hep 3B2	IC₅₀	3.5 μM Compound: 1, sibiriquinone a	Inhibition of hypoxia-induced secreted VEGF levels in Hep3B cells after 1 hr by ELISA Inhibition of hypoxia-induced secreted VEGF levels in Hep3B cells after 1 hr by ELISA	[PMID: 17583950]

In Vitro

Sibiriquinone A (5-80 μM, 72 h) inhibits the lymphocyte transformation in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 723300-08-1
Molecular Weight 280.36
Formula C₁₉H₂₀O₂
SMILES

O=C1C=C(C(C)C)C(C2=C1C(C=CCC3(C)C)=C3C=C2)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gao W, Zhang R, Jia W, Zhang J, Takaishi Y, Duan H. Immunosuppressive diterpenes from Veronicastrum sibiricum. Chem Pharm Bull (Tokyo). 2004 Jan;52(1):136-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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