Steroid sulfatase/17β-HSD1-IN-4 

Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC₅₀ value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases^[1].

IC50: 63 nM (hSTS)^[1].

Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC₅₀ value of 63 nM and acts on irreversible inhibition of hSTS with an IC₅₀ value of 60 nM in T47D human breast cancer cells^[1].
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (20 μM, 48 h) inhibits HEK-293 cells growth by 15.1% at a concentration of 20 μM with low cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

403.48

C₁₈H₁₇N₃O₄S₂

O=S(OC1=CC=C(C2=NC(C(N(C)C3=CC=CC=C3C)=O)=CS2)C=C1)(N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Abdelrahman Mohamed, et al. Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem. 2022 Aug 22.  [Content Brief]