Steroid sulfatase/17β-HSD1-IN-4
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases.
For research use only. We do not sell to patients.
- CAS No.: 2990549-94-3
- Formula: C18H17N3O4S2
- Molecular Weight:403.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 63 nM (hSTS)[1].
In Vitro
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC50 value of 63 nM and acts on irreversible inhibition of hSTS with an IC50 value of 60 nM in T47D human breast cancer cells[1].
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (20 μM, 48 h) inhibits HEK-293 cells growth by 15.1% at a concentration of 20 μM with low cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2990549-94-3
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Molecular Weight 403.48
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Formula C18H17N3O4S2
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SMILES
O=S(OC1=CC=C(C2=NC(C(N(C)C3=CC=CC=C3C)=O)=CS2)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Steroid sulfatase/17β-HSD1-IN-4 Related Classifications
HY-151202 Related Classifications
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