2. Metabolic Enzyme/Protease
  3. Steroid Sulfatase
  4. Steroid sulfatase/17β-HSD1-IN-5

Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research.

For research use only. We do not sell to patients.

Steroid sulfatase/17β-HSD1-IN-5 Chemical Structure

Steroid sulfatase/17β-HSD1-IN-5 Chemical Structure

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Steroid sulfatase/17β-HSD1-IN-5 Related Antibodies

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Description

Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research[1].

IC50 & Target

IC50: 43 nM (17β-HSD 1)[1]
IC50: 6.3 μM (17β-HSD 2)[1]
IC50: 0.4 μM (Steroid sulfatase)[1]
In Vitro

Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) (0-40 μM；48-72 hour) has no effect on cell viability up to 31 μM (HEK293) and 23 μM (HepG2), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Steroid sulfatase/17β-HSD1-IN-5 Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293 and HepG2 cells
Concentration: 0-30 μΜ
Incubation Time: 48-72 hours
Result: Had no effect on cell viability up to 31 μM (HEK293) and 23 μM (HepG2), respectively.
In Vivo

Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) (50 mg.kg for s.c.;single dose) shows a T1/2z of 3.82 h and Cmax obs of 2824 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (Pharmacokinetic assay)[1]
Dosage: 50 mg/kg
Administration: Subcutaneous injection (s.c.), single dose
Result: Pharmacokinetic parameters for Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) in female C57BL/6 mice [1]
Route Dose (mg/kg) Cmax obs (nM) C24 (nM) T1/2z (h) AUC0-24 (ng•h/mL)
s.c. 50 2824 797 3.82 11600
Molecular Weight

430.47

Formula

C21H22N2O6S
SMILES

O=C(C1=CC=C(O1)C2=CC(C)=C(C(C)=C2)O)N(C)C3=C(C=C(C=C3)OS(=O)(N)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Steroid sulfatase/17β-HSD1-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Steroid sulfatase/17β-HSD1-IN-5Steroid SulfataseSteroid sulfataseendometriosis17β-HSD117β-HSD2HEK293HepG2Inhibitorinhibitorinhibit

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