Steroid sulfatase/17β-HSD1-IN-5
Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research.
For research use only. We do not sell to patients.
- CAS No.: 3033655-07-8
- Formula: C21H22N2O6S
- Molecular Weight:430.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 43 nM (17β-HSD 1)[1]
IC50: 6.3 μM (17β-HSD 2)[1]
IC50: 0.4 μM (Steroid sulfatase)[1]
Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) (0-40 μM；48-72 hour) has no effect on cell viability up to 31 μM (HEK293) and 23 μM (HepG2), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 and HepG2 cells
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Concentration:0-30 μΜ
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Incubation Time:48-72 hours
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Result:Had no effect on cell viability up to 31 μM (HEK293) and 23 μM (HepG2), respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57BL/6 mice (Pharmacokinetic assay)[1]
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Dosage:50 mg/kg
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Administration:Subcutaneous injection (s.c.), single dose
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Result:Pharmacokinetic parameters for Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) in female C57BL/6 mice [1]
Route Dose (mg/kg) Cmax obs (nM) C24 (nM) T1/2z (h) AUC0-24 (ng•h/mL) s.c. 50 2824 797 3.82 11600 
Chemical Information
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CAS No. 3033655-07-8
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Molecular Weight 430.47
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Formula C21H22N2O6S
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SMILES
O=C(C1=CC=C(O1)C2=CC(C)=C(C(C)=C2)O)N(C)C3=C(C=C(C=C3)OS(=O)(N)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Select Batch:Purity: 99.98%Assay: 99.98%ee.: 99.98%
References
Calculators
Molarity CalculatorMass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)= × ×Dilution CalculatorConcentration (start) × Volume (start) = Concentration (final) × Volume (final)
×=×
Steroid sulfatase/17β-HSD1-IN-5 Related Classifications
HY-155010 Related Classifications
Keywords
Assay Types -
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