Tetrahydroaminopterin
Tetrahydroaminopterin (NSC 524120) is a tetrahydropteridine analog and the tetrahydro-reduced derivative of aminopterin. Tetrahydroaminopterin is used for studies on phenylalanine hydroxylase cofactor binding and the structure-activity relationship of tetrahydrobiopterin analogs.
For research use only. We do not sell to patients.
- CAS No.: 14231-41-5
- Formula: C19H24N8O5
- Molecular Weight:444.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Tetrahydroaminopterin (NSC 524120) (up to 1 mM) shows no detectable inhibitory effect on partially purified rat liver phenylalanine hydroxylase in both spectrophotometric assays and tyrosine-forming activity assays[1].
Tetrahydroaminopterin (up to 1 mM; 10 min; 27°C) exhibits no intrinsic cofactor activity in the rat liver phenylalanine hydroxylase-catalyzed conversion of phenylalanine to tyrosine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14231-41-5
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Molecular Weight 444.44
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Formula C19H24N8O5
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SMILES
O=C(CC[C@H](NC(C1=CC=C(C=C1)NCC2NC3=C(N=C(NC3=NC2)N)N)=O)C(O)=O)O
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Synonyms
NSC 524120
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetrahydroaminopterin Related Classifications
HY-117551 Related Classifications
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