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Cat. No.: HY-184977

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Thalidomide-O-CO-NH-C10-COOH

Thalidomide-O-CO-NH-C10-COOH is an E3 Ligase Ligand-Linker Conjugates that can be used in PROTAC synthesis-related studies, such as serving as the E3 ligase ligand-linker conjugate for PROTAC CDK9 degrader-5 (HY-149962).

For research use only. We do not sell to patients.

CAS No.: 2305936-81-4
Formula: C₂₆H₃₃N₃O₈
Molecular Weight:515.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thalidomide-O-CO-NH-C10-COOH Chemical Structure

CAS No.: 2305936-81-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

Thalidomide-O-CO-NH-C10-COOH serves as the E3 ligase ligand-linker conjugate of PROTAC CDK9 degrader-5 (HY-149962), a PROTAC that specifically targets CDK9, with DC₅₀ values of 0.10 μM and 0.14 μM against the CDK942 and CDK955 isoforms, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2305936-81-4
Molecular Weight 515.56
Formula C₂₆H₃₃N₃O₈
SMILES

O=C(NCCCCCCCCCCC(O)=O)COC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tokarski RJ, et al. Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation. European journal of medicinal chemistry. 2023 Jun 05;254:115342. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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Thalidomide-O-CO-NH-C10-COOH

All E3 Ligase Ligand-Linker Conjugates Isoforms