Tubulin polymerization-IN-28
Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2481404-89-9
- Formula: C37H46N2O9
- Molecular Weight:662.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tubulin polymerization-IN-28 (compound-4) (9-381 nM, 48 hours)has a significant inhibitory effect on tumor cells[1]. Tubulin polymerization-IN-28 (compound-4) (10 nM, 48 hours) inhibits microtubule assembly with anti-tumor activity[1]. Tubulin polymerization-IN-28 (compound-4) (10 nM, 48 hours) causes G2/M phase arrest in cells[1]. Tubulin polymerization-IN-28 (compound-4) (10 nM, 24 hours) leads to significant cell apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NQO1-Overexpressing A549, HepG2; Hypoxia-exposed A549 (A549/Hyp), HepG2 (HepG2/Hyp) cells; Taxol-resistant A549 cells (A549/T)
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Concentration:9-381 nM
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Incubation Time:48 hours
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Result:Inhibited A549, HepG2, A549/Hyp, HepG2/Hyp, A549/T with IC50values of 10 nM, 26 nM, 72 nM, 85 nM, 56 nM, 74 nM and 88 nM respectively.
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Cell Line:HepG2
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Concentration:10 nM
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Incubation Time:48 hours
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Result:Showed that Tubulin polymerization-IN-28 converted to CA-4, thereby inhibiting microtubule assembly, in the presence of NQO1.
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Cell Line:HepG2
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Concentration:0 nM，10 nM
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Incubation Time:48 hours
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Result:Resulted in an increase in the percentage of G2/M phase cells from 12.71% to 33.49%.
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Cell Line:HepG2
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Concentration:0 nM，10 nM
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Incubation Time:24 hours
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Result:Showed the apoptosis rate of cells increasing from 6.54% to 23.93%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HepG2 xenograft-bearing BALB/c mice[1]
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Dosage:20 mg/kg, 40 mg/kg
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Administration:Intraperitoneal injection; every day; 17days
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Result:Resulted in 47.49% reduction in tumor growth at a concentration of 20 mg/kg. Resulted in 54.87% reduction in tumor growth at a concentration of 40 mg/kg.
Chemical Information
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CAS No. 2481404-89-9
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Molecular Weight 662.77
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Formula C37H46N2O9
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SMILES
COC1=CC(/C=C\C2=CC(OC)=C(C=C2)OC(N(CCN(C(CC(C)(C3=C(C(C(C)=C(C3=O)C)=O)C)C)=O)C)C)=O)=CC(OC)=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-28 Related Classifications
HY-149021 Related Classifications
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