2481404-89-9
Chemical Structure
Tubulin polymerization-IN-28
- CAS No.: 2481404-89-9
- Formula:C37H46N2O9
- Molecular Weight:662.77
IUPAC Name: (Z)-2-(1-ethyl-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-(trifluoromethyl)phenyl)hydrazine-1-carbothioamide
InChIKey: WSNFGPVUGAKDKP-SEYXRHQNSA-N
SMILES: COC1=CC(/C=C\C2=CC(OC)=C(C=C2)OC(N(CCN(C(CC(C)(C3=C(C(C(C)=C(C3=O)C)=O)C)C)=O)C)C)=O)=CC(OC)=C1OC
Biological Activity: Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research[1].
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Tubulin polymerization-IN-28 | Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research. | |||||||||||||||||||||
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