UFR2709 hydrochloride
UFR2709 hydrochloride is a blood-brain barrier-permeable, non-selective competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChR). UFR2709 hydrochloride exerts anxiolytic effects in adult zebrafish, reduces alcohol-seeking behavior, ethanol consumption and ethanol preference in rats, increases water intake in rats, and does not alter locomotor/grooming activity or body weight in rats. UFR2709 hydrochloride can be used in research related to anxiety disorders, nicotine addiction, alcoholism and alcohol dependence.
For research use only. We do not sell to patients.
- CAS No.: 100609-40-3
- Formula: C13H18ClNO2
- Molecular Weight:255.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
UFR2709 hydrochloride has a theoretical cLogP value of 2.5 and 2.15, and an experimental Log D7.4 value of 1.14, indicating it has the capacity to cross the blood-brain barrier[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
UFR2709 hydrochloride (1-10 mg/kg; i.p.; daily; 17 days) reduces ethanol consumption in alcohol-preferring rats in a dose-dependent manner, with the 2.5 mg/kg daily i.p. dose delivering the greatest efficacy (56.9% reduction in average ethanol intake) without altering body weight[3].
UFR2709 hydrochloride (10 mg/kg; i.p.; single dose) does not alter locomotor or grooming activity in ethanol-naïve UChB rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar-UChB (adult male, 240-280 g, genetically selected alcohol-preferring, naïve to ethanol)[2]
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Dosage:2.5 mg/kg
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Administration:i.p.; daily; 7 days in two separate cycles (days 1-7 and days 63-69)
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Result:Reduced ethanol intake by 52.77% compared to controls in the first stage (days 3-62).
Reduced ethanol intake by 57.22% compared to controls in the second stage (days 63-100).
Reduced total ethanol intake by approximately 55% over the 100-day experiment.
Delayed acquisition of ethanol intake.
Reduced ethanol preference to approximately 60% compared to ~80% in controls.
Lowered total fluid intake during the second stage of the experiment.
Maintained body weight growth curve comparable to controls.
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Animal Model:Wistar-UChB (male, 240-280 g, selectively bred for high ethanol preference, 24-h two-bottle free choice paradigm)[3]
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Dosage:1 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
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Administration:i.p.; daily; 17 days
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Result:Reduced voluntary ethanol intake and increased water intake compared to baseline and saline controls.
Induced a 33.4% reduction in average ethanol intake across the 17-day treatment period at 1 mg/kg dose.
Induced a 56.9% reduction in average ethanol intake across the 17-day treatment period at 2.5 mg/kg dose.
Induced a 35.2% reduction in average ethanol intake across the 17-day treatment period at 5 mg/kg dose.
Induced a 31.3% reduction in average ethanol intake across the 17-day treatment period at 10 mg/kg dose.
Did not affect rat body weight.
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Animal Model:Wistar-UChB (male, ethanol-naïve)[3]
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Dosage:10 mg/kg
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Administration:i.p.; single dose
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Result:Did not affect horizontal locomotor activity compared to saline controls.
Did not affect vertical rearing activity compared to saline controls.
Did not affect grooming behavior compared to saline controls.
Chemical Information
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CAS No. 100609-40-3
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Molecular Weight 255.74
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Formula C13H18ClNO2
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SMILES
O=C(C1=CC=CC=C1)OCC(CCC2)N2C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Viscarra F, et al. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Molecules (Basel, Switzerland). 2020 Jun 30;25(13):2998. [Content Brief]
[3]. Quiroz G, et al. UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Frontiers in pharmacology. 2019;10:1429. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UFR2709 hydrochloride Related Classifications
HY-137231 Related Classifications
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