100609-40-3
Chemical Structure
UFR2709 hydrochloride
- CAS No.: 100609-40-3
- Formula:C13H18ClNO2
- Molecular Weight:255.74
IUPAC Name: (1-methylpyrrolidin-2-yl)methyl benzoate hydrochloride
InChIKey: IJJHQEXZNVTJHI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1)OCC(CCC2)N2C.Cl
Biological Activity: UFR2709 hydrochloride is a blood-brain barrier-permeable, non-selective competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChR). UFR2709 hydrochloride exerts anxiolytic effects in adult zebrafish, reduces alcohol-seeking behavior, ethanol consumption and ethanol preference in rats, increases water intake in rats, and does not alter locomotor/grooming activity or body weight in rats. UFR2709 hydrochloride can be used in research related to anxiety disorders, nicotine addiction, alcoholism and alcohol dependence[1][2][3].
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UFR2709 hydrochloride | UFR2709 hydrochloride is a blood-brain barrier-permeable, non-selective competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChR). UFR2709 hydrochloride exerts anxiolytic effects in adult zebrafish, reduces alcohol-seeking behavior, ethanol consumption and ethanol preference in rats, increases water intake in rats, and does not alter locomotor/grooming activity or body weight in rats. UFR2709 hydrochloride can be used in research related to anxiety disorders, nicotine addiction, alcoholism and alcohol dependence. | |||||||||||||||||||||
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References
- [1]. Viscarra F, et al. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Molecules (Basel, Switzerland). 2020 Jun 30;25(13):2998. [Content Brief]
- [2]. Gálvez G, et al. UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats. Biomedicines. 2022 Jun 22;10(7):1482.
- [3]. Quiroz G, et al. UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Frontiers in pharmacology. 2019;10:1429. [Content Brief]
