Umbelopsisin A
Umbelopsisin A is a GABAA and GABAB non-selective agonist. Umbelopsisin A activates the GABAergic pathway, including notch signaling and fatty acid metabolism. Umbelopsisin A shows dual neuroprotection against glutamate excitotoxicity in vitro (reducing ROS and cell death) and in vivo. Umbelopsisin A can be used for the study of glaucoma and broader neurodegenerative disease applications.
For research use only. We do not sell to patients.
- Formula: C21H19NO5
- Molecular Weight:365.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Umbelopsisin A (0.5 μM-16 μM; 24 h; R28 cells) rescues R28 cells from Glu-induced excitotoxicity and reduces ROS production[1].
Umbelopsisin A (2 μM; 24 h; R28 cells) modulates gene expression in R28 cells, promoting axonogenesis and GABA-related pathways[1].
Umbelopsisin A (20 μM-400 μM; 24 h; R28 cells) acts as a GABA receptor agonist, directly binding to GABA_A and GABA_B receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:R28 cells
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Concentration:0.5 μM, 1 μM, 2 μM, 3 μM, 4 μM, 8 μM, 16 μM
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Incubation Time:24 h
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Result:Partially restored glutamate (Glu)-induced cell viability reduction.
Significantly reduced Glu-induced R28 cell death and ROS production, with 2 μM showing significant protection.
At 16 μM, significantly reduced cell viability compared to the Glu group.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 8 weeks) bearing NMDA-induced retinal injury[1]
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Dosage:20 μM
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Administration:Intravitreal; 1 μL
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Result:RGCs density was significantly preserved in the central and mid-peripheral retina. NMDA-induced GCC thinning was significantly attenuated. f-ERG and f-VEP wave amplitudes were significantly improved.
Chemical Information
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Molecular Weight 365.38
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Formula C21H19NO5
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SMILES
CC1=C(O)C(C)=C(C)C([C@@]2(C3=CNC4=CC=CC=C43)C(OC)=O)=C1OC2=O
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Structure Classification
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Initial Source
Umbelopsis sp. DWS 372
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Umbelopsisin A Related Classifications
HY-179519 Related Classifications
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