AKR1B10 - aldo-keto reductase family 1 member B10 Gene

Also Known as HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57016

About AKR1B10

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,527,567-134,541,412 (from NCBI)

This gene has 4 transcripts (splice variants), 563 orthologues and 16 paralogues. Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

AKR1B10 Products (1)

mRNA Protein Name
NM_020299.5 NP_064695.3 aldo-keto reductase family 1 member B10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alcohol dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
19013440 GOA
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
12732097 GOA
enables geranylgeranyl reductase activity IDA
IDA: Inferred from direct assay
21187079 GOA
enables indanol dehydrogenase activity IDA
IDA: Inferred from direct assay
20837989 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18056116 GOA
enables retinal dehydrogenase activity IDA
IDA: Inferred from direct assay
21851338 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular detoxification of aldehyde IDA
IDA: Inferred from direct assay
19013440 GOA
involved in daunorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
involved in doxorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
involved in farnesol catabolic process IDA
IDA: Inferred from direct assay
21187079 GOA
involved in retinoid metabolic process IDA
IDA: Inferred from direct assay
12732097 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
21585341 GOA
located in lysosome IDA
IDA: Inferred from direct assay
21585341 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1B10 Protein Structure

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (16 - 291)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member B10

  • ARP

AKR1B10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AKR1B10 O60218 AKR1B15 Homo sapiens C9JRZ8
Anti Tag CoIP
33961781
Intra
AKR1B10 O60218 ACACA Homo sapiens Q13085
Anti Bait CoIP
18056116
Intra
AKR1B10 O60218 ACACA Homo sapiens Q13085
Confocal
18056116
Intra
AKR1B10 O60218 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
AKR1B10 O60218 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

AKR1B10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81368 AKR1B10 Antibody (YA1113) IHC-P Human
HY-P81368A AKR1B10 Antibody (YA1113)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diabetic Cataract

  • Cataract - Diabetic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-105185 Fidarestat Inhibitor 99.63% Unkown

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139696 AKR1B10-IN-1 Inhibitor 99.08% Unkown
HY-W040265 Fenamic acid Inhibitor 98.25% Unkown
HY-RS00533 AKR1B10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-185414 KB05-Biotin / Unkown
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / Unkown
HY-122177 MK181 Inhibitor / Unkown
HY-RS17238 Akr1b10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23692 Akr1b10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKR1B10 RGD RGD:1308277
Others AKR1B10 NCBI