2. Metabolic Enzyme/Protease
  3. Gutathione S-transferase
  4. α-Angelica lactone

α-Angelica lactone 

Cat. No.: HY-N0548 Purity: 98.08%
COA Handling Instructions

α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes.

For research use only. We do not sell to patients.

α-Angelica lactone Chemical Structure

α-Angelica lactone Chemical Structure

CAS No. : 591-12-8

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Based on 1 publication(s) in Google Scholar

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Description

α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes[1][2][3][4].

IC50 & Target

Glutathione-S-thansferase (GST) detoxification enzyme[1][2]
UDP-glucononosyltransferase (UGT) detoxification enzyme[2]
Molecular Weight

98.10

Appearance

Oil

Formula

C5H6O2
CAS No.
SMILES

O=C1OC(C)=CC1
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1019.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 10.1937 mL 50.9684 mL 101.9368 mL
5 mM 2.0387 mL 10.1937 mL 20.3874 mL
10 mM 1.0194 mL 5.0968 mL 10.1937 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (25.48 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (25.48 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (25.48 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

α-Angelica lactone591-12-8Gutathione S-transferaseGlutathione transferasesGSTsNucleophilestereoselectivityregioselectivityγ-carbonelectrophilicvinylogousanticarcinogenGSTUGTchemoprotectiveInhibitorinhibitorinhibit

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