2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. α-MSH TFA

α-MSH TFA  (Synonyms: α-Melanocyte-Stimulating Hormone TFA)

Cat. No.: HY-P0252A Purity: 98.54%
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α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC).

For research use only. We do not sell to patients.

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CAS No. : 171869-93-5

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Based on 23 publication(s) in Google Scholar

Other Forms of α-MSH TFA:

α-MSH TFA Related Antibodies

Top Publications Citing Use of Products

    α-MSH TFA purchased from MedChemExpress. Usage Cited in: Colloids Surf B Biointerfaces. 2025 Jul 24:255:114979.  [Abstract]

    α-MSH (0.3 μmol/L; 72 h). Effects of PT8 on the expression of cAMP signaling pathway-related factors in B16 cells. Relative quantification of MITF mRNA levels through quantitative PCR after treatment with PT8.

    α-MSH TFA purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 May 15:470:134112.  [Abstract]

    α-MSH (0.1  μM; 48  h). Number of B16-F10 cells. Positive group: α-MSH.

    α-MSH TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 15;14(1):5740.  [Abstract]

    Western blotting of the indicated proteins in B16F10-dCas9 cells transduced with NTC sgRNA or Mc1r sgRNA. Cells were untreated or treated with 1  µM α-MSH (1  µM; 1  h) for 1  h. A representative result is shown from two independent experiments.

    α-MSH TFA purchased from MedChemExpress. Usage Cited in: Blood Adv. 2023 Jul 11;7(13):3199-3212.  [Abstract]

    α-MSH (1 mg/kg; i.p.; once a day for a total of 7 days). Cell cycle analysis of LT-HSCs from the BM of WT mice treated with saline or α-MSH along with vehicle, MK-2206, or PD325901 (n = 6).

    α-MSH TFA purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Sep 10;12(1):501.  [Abstract]

    α-MSH (200 nM; 48 h). The effects of hAMSC-CM or hAESC-CM on tyrosinase enzyme activity are confirmed by treatment with L-DOPA and detection of tyrosinase at 475 nm.

    View All Melanocortin Receptor Isoform Specific Products:

    View All Isoforms
    MC1R MC3R MC2R MC4R MC5R

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    Description

    α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2].

    IC50 & Target

    MC4R

     

    In Vitro

    α-MSH TFA modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH TFA modulates NFκB activation. α-MSH TFA inhibits translocation of transcription factor κB to the nucleus[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    α-MSH TFA Related Antibodies
    In Vivo

    α-MSH TFA (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Formula

    C77H109N21O19S.xC2HF3O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
    Sequence Shortening

    Ac-SYSMEHFRWGKPV-NH2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light, under nitrogen

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (Need ultrasonic)

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    Purity & Documentation
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    α-MSH TFA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    α-MSH171869-93-5α-Melanocyte-Stimulating HormoneMelanocortin ReceptorMC ReceptorendogenousneuropeptideantipyreticMC4RInhibitorinhibitorinhibit

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