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  3. 1,4-Bis(diphenylphosphino)butane

1,4-Bis(diphenylphosphino)butane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

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1,4-Bis(diphenylphosphino)butane

1,4-Bis(diphenylphosphino)butane Chemische Struktur

CAS. Nr. : 7688-25-7

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Beschreibung

1,4-Bis(diphenylphosphino)butane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cellular Effect
Cell Line Type Value Description References
B16 IC50
> 100 μM
Compound: 30
In vitro cytotoxicity against murine B16 melanoma cells
In vitro cytotoxicity against murine B16 melanoma cells
[PMID: 3681888]
In Vitro

1,4-Bis(diphenylphosphino)butane is used in Suzuki reaction. It plays an essential role as a ligand in palladium(0)-catalyzed acylcyanation of arylacetylenes and deprotection of allyloxycarbamates. It acts as a ligand for alkylations, isomerization react ions and in organometallic chemistry. Furthermore, it is used in Heck reaction, Negishi coupling and Sonogashira coupling. In addition to this, it is useful in organometallic chemistry.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

426.47

Formel

C28H28P2

CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

C4=C(P(C1=CC=CC=C1)CCCCP(C2=CC=CC=C2)C3=CC=CC=C3)C=CC=C4

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 4 mg/mL (9.38 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3448 mL 11.7242 mL 23.4483 mL
5 mM 0.4690 mL 2.3448 mL 4.6897 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.0%

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3448 mL 11.7242 mL 23.4483 mL 58.6208 mL
5 mM 0.4690 mL 2.3448 mL 4.6897 mL 11.7242 mL
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1,4-Bis(diphenylphosphino)butane Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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