Cyjohnphos
Based on 1 Customer Validation
CyJohnPhos (2-(Dicyclohexylphosphino)biphenyl) is an organophosphine ligand. Gold (I) complexes derived from CyJohnPhos exhibit anti-colon cancer activity, inhibit the enzymatic activities of COX-1/COX-2 and TrxR, upregulate ROS levels, induce cell apoptosis, and some derivatives can induce cell cycle arrest. CyJohnPhos can serve as an intermediate for research related to organic synthesis.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 247940-06-3
- Formula: C24H31P
- Molecular Weight:350.49
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CyJohnPhos-derived gold (I) complexes exhibit antiproliferative activity against Caco-2/TC7 colon cancer cells. The representative complex [Au (L4)(CyJohnPhos)]SbF6 (4a) has a selectivity index of 7.47. It inhibits COX-1, COX-2 and TrxR, increases intracellular ROS levels in a concentration-dependent manner, induces tumor cell apoptosis, and triggers G1-phase cell cycle arrest[1].
CyJohnPhos (2-(dicyclohexylphosphino) bipheny) (10 mol %) catalyzes the direct arylation of N-substituted indoles, N-substituted pyrroles, and furan substrates with aryl chlorides[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 247940-06-3
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Appearance Solid
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Molecular Weight 350.49
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Formula C24H31P
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Color White to off-white
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SMILES
C1(C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2)=CC=CC=C1
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Synonyms
2-(Dicyclohexylphosphino)biphenyl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyjohnphos Related Classifications
HY-W002849 Related Classifications
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