247940-06-3
Chemical Structure
Cyjohnphos
Synonym(s): 2-(Dicyclohexylphosphino)biphenyl
- CAS No.: 247940-06-3
- Formula:C24H31P
- Molecular Weight:350.49
IUPAC Name: [1,1'-biphenyl]-2-yldicyclohexylphosphane
InChIKey: LCSNDSFWVKMJCT-UHFFFAOYSA-N
SMILES: C1(C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2)=CC=CC=C1
Biological Activity: CyJohnPhos (2-(Dicyclohexylphosphino)biphenyl) is an organophosphine ligand. Gold (I) complexes derived from CyJohnPhos exhibit anti-colon cancer activity, inhibit the enzymatic activities of COX-1/COX-2 and TrxR, upregulate ROS levels, induce cell apoptosis, and some derivatives can induce cell cycle arrest. CyJohnPhos can serve as an intermediate for research related to organic synthesis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyjohnphos | 98.0% | CyJohnPhos (2-(Dicyclohexylphosphino)biphenyl) is an organophosphine ligand. Gold (I) complexes derived from CyJohnPhos exhibit anti-colon cancer activity, inhibit the enzymatic activities of COX-1/COX-2 and TrxR, upregulate ROS levels, induce cell apoptosis, and some derivatives can induce cell cycle arrest. CyJohnPhos can serve as an intermediate for research related to organic synthesis. | ||||||||||||||||||||
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- [1]. Saez J, et al. Gold(I) Complexes Based on Nonsteroidal Anti-Inflammatory Derivatives as Multi-Target Drugs against Colon Cancer. Inorganic chemistry. 2024 Oct 21;63(42):19769-19782. [Content Brief]
- [2]. Nadres ET, et al. Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides. The Journal of organic chemistry. 2011 Jan 21;76(2):471-83.
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