2-Deoxy-2-fluoro-L-fucose (GMP)
2-Deoxy-2-fluoro-L-fucose (2-Fluorofucose) GMP is a fucosyltransferase inhibitor that inhibits core fucosylation modification in cells. 2-Deoxy-2-fluoro-L-fucose GMP promotes the production of defucosylated IgG1 antibodies in IgG1-expressing cell culture systems; it regulates the levels of inflammatory cytokines such as IL-1β, IL-6 and TGF-β in human induced pluripotent stem cell-derived microglia. 2-Deoxy-2-fluoro-L-fucose GMP can be used in the research of related diseases including dengue fever and Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 70763-62-1
- Formula: C6H11FO4
- Molecular Weight:166.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
2-Deoxy-2-fluoro-L-fucose GMP (250 μM; 96 h) treatment of Expi293F cells producing anti-DENV2 E protein IgG1 (C10), anti-CD4 IgG1 (YTS191), or Rituximab (HY-P9913) IgG1 generates afucosylated IgG1s that bind human FcγRIIIA with high affinity (Kd values as low as 39 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
2-Deoxy-2-fluoro-L-fucose GMP (250 µM; cell culture supplementation during antibody expression) induces production of afucosylated anti-DENV2 E protein IgG1 C10, which drives severe dengue infection in Ifnar1-/-/FcγR humanized mice, matching the pathogenicity of monofucosylated C10[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:FcγR humanized mice (males or females; 6-12 weeks old; CD4+ T cell depletion model via anti-CD4 IgG1 YTS191 injection)[1]
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Dosage:10 µg
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Administration:i.v.; single dose
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Result:Reduced the frequency of CD4+ T cells over total CD3+ T cells to levels similar to those induced by monofucosylated YTS191.
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Animal Model:Ifnar1-/-/FcγR humanized mice (male and female; 4-5 weeks old; antibody-dependent enhancement of dengue disease model via DENV2 virus challenge)[1]
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Dosage:20 µg
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Administration:i.v.; single dose
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Result:Induced significantly lower body weight and reduced survival in mice upon DENV2 challenge, with outcomes identical to those induced by monofucosylated C10, and significantly more severe than those induced by bifucosylated or FcR null C10.
Chemical Information
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CAS No. 70763-62-1
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Molecular Weight 166.15
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Formula C6H11FO4
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SMILES
O=C[C@@H](F)[C@@H]([C@@H]([C@H](C)O)O)O
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Synonyms
2-Fluorofucose (GMP)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Deoxy-2-fluoro-L-fucose (GMP) Related Classifications
HY-116705G Related Classifications
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