3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl

製品番号: HY-N17845: Data Sheet 取扱説明書
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3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl, a stilbenoid compound, is a tubulin inhibitor with an IC₅₀ of 10 μM. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl inhibits tubulin polymerization. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl functions as a potentiator that potentiates SN-38 (HY-13704) cytotoxicity in BCRP-transduced cancer cells. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl can be used for the study of breast cancer.

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3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl 構造式

CAS 番号 : 87530-27-6

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製品説明	3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl, a stilbenoid compound, is a tubulin inhibitor with an IC₅₀ of 10 μM. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl inhibits tubulin polymerization. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl functions as a potentiator that potentiates SN-38 (HY-13704) cytotoxicity in BCRP-transduced cancer cells. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl can be used for the study of breast cancer^[1].
体外実験	3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl (compound 4) (10 μM) inhibits purified tubulin protein polymerization with an IC₅₀ of 10 μM^[1]. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl (compound 4) (3 μM; 5 days) reverses BCRP-mediated SN-38 resistance in K562/BCRP cells with a reversal index of 3.0^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl 関連抗体
分子量	456.53
分子式	C₂₉H₂₈O₅
CAS 番号	87530-27-6
SMILES	OC1=CC=C(CC2=C(C=C(C(CC3=CC=C(C=C3)O)=C2CCC4=CC(O)=CC=C4)OC)O)C=C1
Structure Classification	Phenylpropanoids Simple Phenylpropanols
Initial Source	Plants Orchidaceae Bletilla striata (Thunb. ex Murray) Rchb. f.
輸送条件	Room temperature in continental US; may vary elsewhere.
保管条件	Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション	データシート (268 KB) 取扱説明書 (2659 KB)
参考文献	[1]. Morita H, et al. Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata. Bioorg Med Chem Lett. 2005;15(4):1051-1054. [Content Brief]