3,4-Dibromo-Mal-PEG4-Acid

Cat. No.: HY-W591402 Purity: 95.20%: Data Sheet
COA

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Handling Instructions
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3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

For research use only. We do not sell to patients.

3,4-Dibromo-Mal-PEG4-Acid Chemical Structure

CAS No. : 2434639-17-3

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Purity & Documentation
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Description

Molecular Weight

503.14

Formula

C₁₅H₂₁Br₂NO₈

CAS No.

2434639-17-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCOCCOCCOCCOCCN1C(C(Br)=C(C1=O)Br)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (198.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9875 mL	9.9376 mL	19.8752 mL
5 mM	0.3975 mL	1.9875 mL	3.9750 mL
10 mM	0.1988 mL	0.9938 mL	1.9875 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.36%

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Data Sheet (239 KB) SDS (252 KB)

COA (243 KB) HNMR (262 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9875 mL	9.9376 mL	19.8752 mL	49.6880 mL
	5 mM	0.3975 mL	1.9875 mL	3.9750 mL	9.9376 mL
	10 mM	0.1988 mL	0.9938 mL	1.9875 mL	4.9688 mL
	15 mM	0.1325 mL	0.6625 mL	1.3250 mL	3.3125 mL
	20 mM	0.0994 mL	0.4969 mL	0.9938 mL	2.4844 mL
	25 mM	0.0795 mL	0.3975 mL	0.7950 mL	1.9875 mL
	30 mM	0.0663 mL	0.3313 mL	0.6625 mL	1.6563 mL
	40 mM	0.0497 mL	0.2484 mL	0.4969 mL	1.2422 mL
	50 mM	0.0398 mL	0.1988 mL	0.3975 mL	0.9938 mL
	60 mM	0.0331 mL	0.1656 mL	0.3313 mL	0.8281 mL
	80 mM	0.0248 mL	0.1242 mL	0.2484 mL	0.6211 mL
	100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.4969 mL