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  3. 5-Geranoxy-7-methoxycoumarin

5-Geranoxy-7-methoxycoumarin 

Cat. No.: HY-N8431
Handling Instructions

5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis.

For research use only. We do not sell to patients.

5-Geranoxy-7-methoxycoumarin Chemical Structure

5-Geranoxy-7-methoxycoumarin Chemical Structure

CAS No. : 7380-39-4

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Description

5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].

In Vitro

5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW480
Concentration: 0-20 μM
Incubation Time: 24, 48 and 72 hours
Result: Inhibited cell growth by 67% at 72 hours.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited cell cycle progression in vitro.
Molecular Weight

328.40

Formula

C₂₀H₂₄O₄

CAS No.
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5-Geranoxy-7-methoxycoumarin
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HY-N8431
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