6-Thioguanosine-5'-O-diphosphate sodium
6-Thioguanosine-5'-O-diphosphate sodium (6-Thio-GDP sodium) (TGDP sodium) is an active metabolite of 6-Mercaptopurine (HY-13677). 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.
For research use only. We do not sell to patients.
- Formula: C10H12N5Na3O10P2S
- Molecular Weight:525.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
Chemical Information
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Molecular Weight 525.21
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Formula C10H12N5Na3O10P2S
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=S)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O
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Synonyms
TGDP sodium; 6-Thio-GDP sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hawwa AF, et al. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine. Br J Clin Pharmacol. 2008 Oct;66(4):517-28. [Content Brief]
[2]. Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1081-92. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Thioguanosine-5'-O-diphosphate sodium Related Classifications
HY-175390 Related Classifications
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