7α,27-Dihydroxycholesterol

Cat. No.: HY-W414548: Data Sheet
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Handling Instructions
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7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).

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7α,27-Dihydroxycholesterol Chemical Structure

CAS No. : 4725-24-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Other Forms of 7α,27-Dihydroxycholesterol:

7α,27-Dihydroxycholesterol-d₆ In-stock

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Description

Molecular Weight

418.65

Formula

C₂₇H₄₆O₃

CAS No.

4725-24-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)CO)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@H]3O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (23.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3886 mL	11.9432 mL	23.8863 mL
5 mM	0.4777 mL	2.3886 mL	4.7773 mL
10 mM	0.2389 mL	1.1943 mL	2.3886 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.9%

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Data Sheet (242 KB) SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3886 mL	11.9432 mL	23.8863 mL	59.7158 mL
	5 mM	0.4777 mL	2.3886 mL	4.7773 mL	11.9432 mL
	10 mM	0.2389 mL	1.1943 mL	2.3886 mL	5.9716 mL
	15 mM	0.1592 mL	0.7962 mL	1.5924 mL	3.9811 mL
	20 mM	0.1194 mL	0.5972 mL	1.1943 mL	2.9858 mL