2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. 9β,10β-epoxy Hexahydrocannabinol

9β,10β-epoxy Hexahydrocannabinol  (Synonyms: 9β,10β-EHHC; 9β,10β-epoxy HHC)

Cat. No.: HY-179436
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9β,10β-epoxy Hexahydrocannabinol is a cannabinoid receptor 1 (CB1) and CB2 receptor ligand with a binding affinity of 224 nM for CB1 and 335 nM for CB2. 9β,10β-epoxy Hexahydrocannabinol reduces locomotor activity, induces catalepsy, lowers body temperature, and produces antinociceptive effects in mice. 9β,10β-epoxy Hexahydrocannabinol can be used for the study of nervous system diseases.

For research use only. We do not sell to patients.

9β,10β-epoxy Hexahydrocannabinol

9β,10β-epoxy Hexahydrocannabinol Chemical Structure

CAS No. : 1781270-07-2

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9β,10β-epoxy Hexahydrocannabinol Related Antibodies

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Description

9β,10β-epoxy Hexahydrocannabinol is a cannabinoid receptor 1 (CB1) and CB2 receptor ligand with a binding affinity of 224 nM for CB1 and 335 nM for CB2. 9β,10β-epoxy Hexahydrocannabinol reduces locomotor activity, induces catalepsy, lowers body temperature, and produces antinociceptive effects in mice. 9β,10β-epoxy Hexahydrocannabinol can be used for the study of nervous system diseases[1].

IC50 & Target[1]

CB1

224 nM (Ki)

CB2

335 nM (Ki)

In Vitro

9β,10β-epoxy Hexahydrocannabinol binds to human CB1 and CB2 receptors with affinities of 224 nM and 335 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9β,10β-epoxy Hexahydrocannabinol Related Antibodies
In Vivo

9β,10β-epoxy Hexahydrocannabinol (5-20 mg/kg; i.p.; single dose) exerts potent cannabimimetic-like effects in healthy mice, including hypolocomotion, catalepsy, antinociception, and hypothermia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster (male, 8 weeks old, 24-30 g)[1]
Dosage: 5, 10, 20 mg/kg
Administration: i.p.; single dose
Result: Caused significant hypolocomotion, significant catalepsy (latency increase), significant hot-plate antinociception, and a significant decrease in rectal temperature.
Molecular Weight

330.46

Formula

C21H30O3
CAS No.
SMILES

C[C@]12[C@](O2)([H])[C@@]3([H])C4=C(O)C=C(CCCCC)C=C4OC(C)([C@]3([H])CC1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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9β,10β-epoxy Hexahydrocannabinol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9β,10β-epoxy Hexahydrocannabinol1781270-07-29β,10β-EHHC 9β,10β-epoxy HHCCannabinoid ReceptorCB2 receptormicehuman CB1Cannabis sativaCB1 receptorhuman CB2mouse tetrad assaysInhibitorinhibitorinhibit

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