NE-100 hydrochloride
Based on 1 publication(s) in Google Scholar
NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases.
For research use only. We do not sell to patients.
- Purity: 99.1%
- CAS No.: 149409-57-4
- Formula: C23H34ClNO2
- Molecular Weight:391.97
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Neuronal Signaling Compound Library
HY-L013
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Anti-Aging Compound Library
HY-L034
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Endoplasmic Reticulum Stress Compound Library
HY-L054
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Orally Active Compound Library
HY-L061
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Neuroprotective Compound Library
HY-L070
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Human Metabolite Library
HY-L123
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Pain-Related Compound Library
HY-L139
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
Publications Citing Use of MedChemExpress (MCE) NE-100 hydrochloride
MoreAll Sigma Receptor Isoforms
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Biological Activity
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Sigma 1 Receptor 4.16 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10000 nM
Compound: 2, NE-100
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Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells
Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells
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[PMID: 21555222] |
| HEK293 | IC50 |
>10000 nM
Compound: 2, NE-100
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Displacement of [3H]N-methylspiperone from human D2 receptor expressed in HEK cells
Displacement of [3H]N-methylspiperone from human D2 receptor expressed in HEK cells
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[PMID: 21555222] |
NE-100 (0.1-3 µM; 1-25 h) hydrochloride inhibits cell death and regulates the expression of endoplasmic reticulum stress-related proteins in Tunicamycin (HY-A0098)-treated HT22 cells. The mechanism involves activation of the ATF6 pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Tunicamycin (HY-A0098)-treated HT22 cells
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Concentration:3 µM
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Incubation Time:Pretreated with 1 h, then co-incubation for 24 h
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Result:Inhibited the protein level of CHOP.
NE-100 (0.03-1 mg/kg; oral administration; single dose) hydrochloride improves cognitive impairment in rat models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (80-120 g) treated (+)SKF10047 (HY-101376) or phencyclidine to induce head-weaving behavior model[2]
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Dosage:/
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Administration:Oral administration; single dose
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Result:Dose-dependently antagonized (+)SKF10047 (HY-101376) or phencyclidine induced head-weaving behavior with oral ED50 at 0.27 and 0.12 mg/kg, respectively.
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Animal Model:Male Wistar rats (~250 g) treated phencyclidine to induce delayed cognitive dysfunction[3]
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Dosage:0.03, 0.1 and 0.3 mg/kg (before the first trial of the water maze test)
0.1, 0.3 and 1 mg/kg (after phencyclidine injection) -
Administration:Oral administration; single dose
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Result:Significantly and dose-dependently reduced the escape latency of rats in the water maze task, indicating improvement of phencyclidine-induced delayed cognitive dysfunction.
Had lower effective doses when administered before the trial (late intervention) compared to administration after phencyclidine injection (early intervention).
Chemical Information
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CAS No. 149409-57-4
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Appearance Solid
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Molecular Weight 391.97
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Formula C23H34ClNO2
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Color White to light yellow
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SMILES
CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Redox Biol
Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS. [Abstract]2025 Sep 20:87:103875. PMID: 40992079
Solvent & Solubility
H2O : ≥ 100 mg/mL (255.12 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434(4):904-9. [Content Brief]
[2]. Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53(18):PL285-90. [Content Brief]
[3]. Okuyama S, et al. Effect of NE-100, a novel sigma receptor ligand, on phencyclidine- induced delayed cognitive dysfunction in rats. Neurosci Lett. 1995 Apr 7;189(1):60-2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.5512 mL | 12.7561 mL | 25.5122 mL | 63.7804 mL |
| 5 mM | 0.5102 mL | 2.5512 mL | 5.1024 mL | 12.7561 mL | |
| 10 mM | 0.2551 mL | 1.2756 mL | 2.5512 mL | 6.3780 mL | |
| 15 mM | 0.1701 mL | 0.8504 mL | 1.7008 mL | 4.2520 mL | |
| 20 mM | 0.1276 mL | 0.6378 mL | 1.2756 mL | 3.1890 mL | |
| 25 mM | 0.1020 mL | 0.5102 mL | 1.0205 mL | 2.5512 mL | |
| 30 mM | 0.0850 mL | 0.4252 mL | 0.8504 mL | 2.1260 mL | |
| 40 mM | 0.0638 mL | 0.3189 mL | 0.6378 mL | 1.5945 mL | |
| 50 mM | 0.0510 mL | 0.2551 mL | 0.5102 mL | 1.2756 mL | |
| 60 mM | 0.0425 mL | 0.2126 mL | 0.4252 mL | 1.0630 mL | |
| 80 mM | 0.0319 mL | 0.1595 mL | 0.3189 mL | 0.7973 mL | |
| 100 mM | 0.0255 mL | 0.1276 mL | 0.2551 mL | 0.6378 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NE-100 hydrochloride Related Classifications
HY-101484A Related Classifications
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