Lonchocarpus sericeus (Poir.) Kunth ex DC.
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Lonchocarpus sericeus (Poir.) Kunth ex DC. (1)
Lonchocarpin
Cat. No.: HY-119590
CAS No.: 31501-55-0
Synonyms: Lonchocarpine
- Formula: C20H18O3
- Molecular Weight: 306.36
Lonchocarpin (Lonchocarpine) is a Wnt/β-catenin signaling pathway inhibitor. The IC50 of Lonchocarpin in SW480 pBAR/Renilla cells is 4 μM. Acting downstream of β-catenin stabilization, Lonchocarpin inhibits β-catenin nuclear localization and TCF-mediated transcription, as well as the proliferation and migration of colorectal cancer cells. Lonchocarpin enhances Nrf2/ARE-mediated antioxidant responses in primary astrocytes via AMPK and JNK-related signaling, reduces H2O2-induced ROS production, and increases the expression of HO-1, NQO1 and MnSOD. Lonchocarpin can be used in research on colorectal cancer and oxidative stress.
