Penthorum chinense Pursh

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a TRPV1 antagonist and HDAC7 inhibitor. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside blocks TRPV1-mediated calcium influx, suppresses phosphorylation of p65, IκBα, p38, JNK, and ERK1/2, inhibiting NF-κB and MAPK signaling cascades. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside reduces production and gene expression of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside exhibits potent analgesic activity, elevates thermal pain threshold and mechanical pain threshold in murine models. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside restores CD8⁺ T cell infiltration into bladder cancer tumors and improves bladder cancer immunotherapy efficacy. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can be used for the researches of painand bladder cancer.

Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is is a flavanone that enhances lipid peroxidation.

(Rac)-Pinocembrin-7-O-β-D-glucoside is the racemate of Pinocembrin-7-O-β-D-glucoside (HY-N6616). Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is a flavonoid compound that enhances lipid peroxidation.

Penthorum chinense pursh extract is an extract isolated fromPenthorum chinense pursh.

Penthorum chinense polysaccharide is a polysaccharide derived from Penthorum chinense.

2',4',6'-Trihydroxydihydrochalcone-4'-O-(3''-O-galloyl)glucoside is a natural chalcone.

(7'E,8S)-2',4,8-Trihydroxy-3-methoxy-2,4'-epoxy-8,5'-neolign-7'-en-7-one (compound 4) is a novel neolignan anti-inflammatory agent. (7'E,8S)-2',4,8-Trihydroxy-3-methoxy-2,4'-epoxy-8,5'-neolign-7'-en-7-one has an IC₅₀ of 25.2 μM against TGF-β-induced hepatic stellate cells (HSC-T6). (7'E,8S)-2',4,8-Trihydroxy-3-methoxy-2,4'-epoxy-8,5'-neolign-7'-en-7-one may be related to blocking excessive cell proliferation in the process of liver fibrosis and can be used in the study of liver fibrosis-related diseases. (7'E,8S)-2',4,8-Trihydroxy-3-methoxy-2,4'-epoxy-8,5'-neolign-7'-en-7-one can be naturally extracted from the dried aerial parts of Penthorum chinense Pursh.

2,6-Dihydroxyacetophenone-4-O-[4,6-(S)-hexahydroxydiphenoyl]-β-D-glucose is a novel polyphenol/ellagitannin-type glucoside. 2,6-Dihydroxyacetophenone-4-O-[4,6-(S)-hexahydroxydiphenoyl]-β-D-glucose mediates antiproliferative effects via platelet-derived growth factor (PDGF)-induced hepatic stellate cells. 2,6-Dihydroxyacetophenone-4-O-[4,6-(S)-hexahydroxydiphenoyl]-β-D-glucose can be used for the research of hepatic fibrosis.

Pinocembrin-7-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinocembrin-7-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pinocembrin-7-O-β-D-glucopyranoside (Pinocembrin 7-O-β-D-Glucoside) is is a flavanone that enhances lipid peroxidation.

Pinocembrin 7-O-[4′′,6′′-(S)-HHDP]-β-D-glucoside (compound 3) is a polyphenol that has weak antiproliferative activity in PDGF-induced HSC-T6 cells (IC50: 200 μM).

5-MethoxyPinocembroside is a flavonoid isolated from Penthorumchinense Pursh. 5-MethoxyPinocembroside has demonstrated a specific pharmacological effect against hepatic steatosis.