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Cat. No.: HY-112441

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Prolyl Hydroxylase inhibitor 1

Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC₅₀ of 62.23 nM. Antianemia agent.

For research use only. We do not sell to patients.

CAS No.: 2205125-60-4
Formula: C₁₉H₁₈ClN₅O₄
Molecular Weight:415.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Prolyl Hydroxylase inhibitor 1 Chemical Structure

CAS No.: 2205125-60-4

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC₅₀ of 62.23 nM^[1]. Antianemia agent^[1].

IC₅₀ & Target

IC50: 62.23±2.33nM (HIF-PHD)^[1]

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Chemical Information

CAS No. 2205125-60-4
Molecular Weight 415.83
Formula C₁₉H₁₈ClN₅O₄
SMILES

O=C(NCC(O)=O)C1=C(O)C=C(C2=CN(CCCC3=CC=C(Cl)C=C3)N=N2)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu Y, et al. Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia. J Med Chem. 2018 Ju [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Prolyl Hydroxylase inhibitor 1

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Prolyl Hydroxylase inhibitor 1 Related Classifications

HY-112441 Related Classifications